Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Aggrecan (PG) Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:PG
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RIS001R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum

Sample Requirements

50 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

10–150 ng/ml

Limit of Detection

0.9 ng/ml

Summary

Research topic

Bone and cartilage metabolism

Summary

Aggrecan (PG) is the predominant proteoglycan species in articular cartilage. The loss of PG and other matrix components from the cartilage leads to destruction of the tissue, causing complete deterioration of the articular surface. PG and PG fragments released in synovial fluid and serum during this degradation process might serve as markers of the metabolic changes in diseased cartilage.

References to Summary

References to Aggrecan

  • Bassleer C, Henrotin Y, Franchimont P. Insulin-Like Growth factor 1 and Glycosaminoglycan-Peptide Complex: Their Effects on Differentiated Human Chondrocytes Cultivated in Clusters. Litera Rheumatologica. 1991;13; 33-44
  • Bassleer C, Henrotin Y, Franchimont P. Effects of a Glycosaminoglycan-Peptide Complex and Interleukin 1 on Differentiated Human Chondrocytes Cultivated in Clusters. Litera Rheumatologica. 1991;13; 21-31
  • Franchimont P, Bassleer C. Effects of hormones and local growth factors on articular chondrocyte metabolism. J Rheumatol Suppl. 1991 Feb;27:68-70
  • Franchimont P, Bassleer C, Henrotin Y. Effects of hormones and drugs on cartilage repair. J Rheumatol Suppl. 1989 Aug;18:5-9
  • Heinegard D, Oldberg A. Structure and biology of cartilage and bone matrix noncollagenous macromolecules. FASEB J. 1989 Jul;3 (9):2042-51
  • Lohmander LS, Lark MW, Dahlberg L, Walakovits LA, Roos H. Cartilage matrix metabolism in osteoarthritis: markers in synovial fluid, serum, and urine. Clin Biochem. 1992 Jun;25 (3):167-74
  • Poole AR, Ionescu M, Swan A, Dieppe PA. Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis. J Clin Invest. 1994 Jul;94 (1):25-33
  • Saxne T, Heinegard D. Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. Arthritis Rheum. 1992 Apr;35 (4):385-90
  • Saxne T, Heinegard D, Wollheim FA. Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. Relation to systemic treatment. Arthritis Rheum. 1987 Sep;30 (9):972-9
Related Products Documents