| Cat. No. | Size |
Price |
|
|---|---|---|---|
| DKO053 | 96 wells (1 kit) |
Competitive ELISA
Serum, Urine, Plasma
Shipped on ice packs. Upon receipt, store the product at the temperature recommended below.
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
20 - 2000 pg/ml
15 pg/ml
The kits are CE-IVD certified and intended for professional use.
European Union: for in vitro diagnostic use
Rest of the world: for research use only!
The total assay time is less than 2.5 hours
Quantitative determination of aldosterone in human serum, plasma and urine
No cross-reactivity with the other steroid hormones
Assay format is 96 wells
Quality Controls (A and B) are ready to use
Standards are ready to use
For routine analysis
Blood pressure regulation and NO metabolism, Bone and cartilage metabolism, Cardiovascular disease, Renal disease, Steroid hormones
Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland, is the most potent mineralocorticoid in humans, it regulate sodium and potassium balance in the blood. Aldosterone secretion appears to be stimulated primarily through the renin-angiotensin system. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone regulate plasma bicarbonate (HCO3-) levels and its acid/base balance. Aldosterone is responsible for the reabsorption of about 2% of filtered sodium in the kidneys. Plasma aldosterone levels normally vary with body position (upright>supine) and salt intake. Overall plasma aldosterone levels show a circadian rhythm which is similar to but less marked than cortisol, with peak levels in the early morning; about 75% of the daily production is secreted between 04:00 am and 10:00 am each day. Age-related levels tend to decline from fetal through adult life. Abnormally high plasma aldosterone concentrations can occur in adenomas, glucocorticoid-responsive hyperaldosteronism, idiopathic. Abnormally low aldosterone secretion occurs in a number of conditions including salt-wasting forms of congenital adrenal hyperplasia, nephropathy, and renal tubular acidosis.
Example Instructions for Use (RUO)