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Calcitonin (CT) Human ELISA, High Sensitivity

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:CT
  • Species:Human
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Cat. No. Size Price


RIS0019R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum

Sample Requirements

100 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

10–400 pg/ml

Limit of Detection

0.7 pg/ml

Summary

Research topic

Bone and cartilage metabolism, Oncology

Summary

Calcitonin(CT) is a 32 amino acid peptide hormone secreted by the para-follicular C-cells of the thyroid gland under serum calcium control. After acute administration, this peptide acts as a potent hypocalcemic and hypophosphatemic hormone by increasing renal calcium clearance and reducing bone resorption. However, its precise physiological role in bone metabolism is not yet fully understood. Various forms of CT may be detected in blood samples, including a CT monomer, an oxidized monomer, a dimer, higher molecular weight forms, and possibly precursor of CT. The concentrations of these peptides vary with clinical status, renal function and tissular origin of CT (normal or ectopic production). Medullar thyroid carcinoma (MTC) is a malignant tumor, developed from the C-cells, secreting calcitonin in large excess. This disease occurs either as a sporadic (80%) or a familial (20%) form, which is transmitted as an autosomal dominant gene or as a component of multiple endocrine neoplasia (IIb). Moderate hypercalcitoninemia is also observed in pregnancy, pernicious anaemia, renal failure and during the neonatal period. Preferably, monomer form of CT is detected in this assay. Clinical application The measurement of CT is used for : - Diagnosis of medullary thyroid carcinoma (MTC), - Follow up of malignant tumors, to check the success of surgery and to monitor for recurrence, - Diagnosis of the preclinical cases of the familial forms of MTC (MEN II or Sipple syndrome) by the use of stimulation tests (calcium or pentagastrin), - Study of the pathophysiology of the calcium-phosphate and bone metabolism.

References to Summary

References to Calcitonin

  • Graze K, Spiler IJ, Tashjian AH Jr, Melvin KE, Cervi-Skinner S, Gagel RF, Miller HH, Wolfe HJ, DeLellis RA, Leape L, Feldman ZT, Reichlin S. Natural history of familial medullary thyroid carcinoma: effect of a program for early diagnosis. N Engl J Med. 1978 Nov 2;299 (18):980-5
  • Hennessy JF, Wells SA Jr, Ontjes DA, Cooper CW. A comparison of pentagastrin injection and calcium infusion as provocative agents for the detection of medullary carcinoma of the thyroid. J Clin Endocrinol Metab. 1974 Sep;39 (3):487-95
  • Niccoli P, Brunet P, Roubicek C, Roux F, Baudin E, Lejeune PJ, Berland Y, Conte-Devolx B. Abnormal calcitonin basal levels and pentagastrin response in patients with chronic renal failure on maintenance hemodialysis. Eur J Endocrinol. 1995 Jan;132 (1):75-81
  • Pacini F, Fontanelli M, Fugazzola L, Elisei R, Romei C, Di Coscio G, Miccoli P, Pinchera A. Routine measurement of serum calcitonin in nodular thyroid diseases allows the preoperative diagnosis of unsuspected sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab. 1994 Apr;78 (4):826-9
  • Quesada JM, Mateo A, Jans I, Rodriguez M, Bouillon R. Calcitriol corrects deficient calcitonin secretion in the vitamin D-deficient elderly. J Bone Miner Res. 1994 Jan;9 (1):53-7
  • Rougier P, Calmettes C, Laplanche A, Travagli JP, Lefevre M, Parmentier C, Milhaud G, Tubiana M. The values of calcitonin and carcinoembryonic antigen in the treatment and management of nonfamilial medullary thyroid carcinoma. Cancer. 1983 Mar 1;51 (5):855-62
  • Wallach SR, Royston I, Taetle R, Wohl H, Deftos LJ. Plasma calcitonin as a marker of disease activity in patients with small cell carcinoma of the lung. J Clin Endocrinol Metab. 1981 Sep;53 (3):602-6
  • Wells SA Jr, Baylin SB, Linehan WM, Farrell RE, Cox EB, Cooper CW. Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland. Ann Surg. 1978 Aug;188 (2):139-41
  • Wells SA Jr, Baylin SB, Linehan WM, Farrell RE, Cox EB, Cooper CW. Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland. Ann Surg. 1978 Aug;188 (2):139-41
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