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Cysticercosis Ag ELISA

  • Regulatory status:RUO
  • Species:Human
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Cat. No. Size Price


RAD650501 96 wells (1 kit)
PubMed Product Details
Technical Data

Storage/Expiration

2–8°C

Note

Sensitivity (IC50): 1 cyst is detectable in certain conditions

Summary

Research topic

Others

Summary

Taenia solium cysticercosis is an infection of humans and pigs with the metacestode larvae (cysticercus) of Taenia solium. Circulating antigen detection in serum is an important diagnostic method that indicates the presence of viable parasites. The monoclonal antibodies (IgG isotype) used in this assay are produced against excretory secretory products (ESP) of viable T. saginata cysticerci (Brandt et al., 1992; Dorny et al., 2004). The glycoprotein antigens detected by these monoclonal antibodies are present on the tegument and in the excretory-secretory-products of metacestodes (Draelants et al., 1995).
The assay only demonstrates the presence of viable cysticerci, it does not detect degenerated or calcified cysticerci. In this respect, unlike antibody detection, measurement of circulating antigen levels allows differentiation of cysticercosis cases with viable parasites, with antigen levels correlating to the numbers and size of lesions. It can as such also provide a tool for serological monitoring of antiparasitic therapy in human or pigs: antigen levels drop rapidly after successful anthelminthic treatment (Deckers & Dorny, 2010).

References to Product

References

Dorny P, Phiri IK, Vercruysse J, Gabriel S, Willingham AL 3rd, Brandt J, Victor B, Speybroeck N, Berkvens D. A Bayesian approach for estimating values for prevalence and diagnostic test characteristics of porcine cysticercosis. Int J Parasitol. 2004 Apr;34 (5):569-76 Brandt JR, Geerts S, De Deken R, Kumar V, Ceulemans F, Brijs L, Falla N. A monoclonal antibody-based ELISA for the detection of circulating excretory-secretory antigens in Taenia saginata cysticercosis. Int J Parasitol. 1992 Jul;22 (4):471-7 Draelants E, Brandt JR, Kumar V, Geerts S. Characterization of epitopes on excretory-secretory antigens of Taenia saginata metacestodes recognized by monoclonal antibodies with immunodiagnostic potential. Parasite Immunol. 1995 Mar;17 (3):119-26 Rodriguez S, Dorny P, Tsang VC, Pretell EJ, Brandt J, Lescano AG, Gonzalez AE, Gilman RH, Garcia HH. Detection of Taenia solium antigens and anti-T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis. J Infect Dis. 2009 May 1;199 (9):1345-52 Deckers N, Dorny P. Immunodiagnosis of Taenia solium taeniosis/cysticercosis. Trends Parasitol. 2010 Mar;26 (3):137-44 Nguekam A, Zoli AP, Vondou L, Pouedet SM, Assana E, Dorny P, Brandt J, Losson B, Geerts S. Kinetics of circulating antigens in pigs experimentally infected with Taenia solium eggs. Vet Parasitol. 2003 Feb 27;111 (4):323-32 Erhart A, Dorny P, Van De N, Vien HV, Thach DC, Toan ND, Cong le D, Geerts S, Speybroeck N, Berkvens D, Brandt J. Taenia solium cysticercosis in a village in northern Viet Nam: seroprevalence study using an ELISA for detecting circulating antigen. Trans R Soc Trop Med Hyg. 2002 May-Jun;96 (3):270-2

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