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Follicle Stimulating Hormone, Human, Native

  • Regulatory status:RUO
  • Type:Native protein
  • Source:Urine of post-menopausal women
  • Other names:Follicle Stimulating Hormone, Follicle-Stimulating Hormon
  • Species:Human
Cat. No. Size Price

Discount RP1782490500 500 IU $281,94
Discount RP1782491000 5000 IU $459,8
Discount RP1782490100 100 IU $153,25
PubMed Product Details
Technical Data


Native protein


FSH Human is a glycoprotein produced from urine of post-menopausal women and having a total molecular mass of 30,000 Dalton. FSH is a heterodimeric hormone consisting of 92 amino acids a chain and 111 amino acids b chain.


Urine of post-menopausal women


Less than: 0.1% hCG, 0.5%TSH, 0.5% LH, 0.5%GH and 0.5%Prl.


Sterile filtered and lyophilized with no additives.


It is recommended to reconstitute the lyophilized Follicle Stimulating Hormone in sterile pyrogen free water at 2,000IU/1ml, which can then be further diluted to other aqueous solutions.


Lyophilized FSH although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FSH-beta should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.


Research topic



Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. FSH and LH act synergistically in reproductionIn women, in the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production. In men, FSH enhances the production of androgen-binding proteinby the Sertoli cells of the testes and is critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle. Like its partner, LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin-releasing hormone(GnRH). Those pulses, in turn, are subject to the estrogen feed-back from the gonads.

Summary References (15)

References to FSH

  • Butt WR, Ryle M, Shirley A. Kinetic studies with 125I-labelled follicle-stimulating hormone. J Endocrinol. 1973 Aug;58 (2):275-87
  • Cohen KL. Metabolic, endocrine, and drug-induced interference with pituitary function tests: a review. Metabolism. 1977 Oct;26 (10):1165-77
  • Jeffcoate SL. The control of testicular function in the adult. Clin Endocrinol Metab. 1975 Nov;4 (3):521-43
  • Jockenhovel F, Khan SA, Nieschlag E. Circulating antibodies to monoclonal immunoglobulins used in a follitropin assay may cause incorrect fertility diagnosis. J Clin Chem Clin Biochem. 1989 Oct;27 (10):825-8
  • Kjeld JM, Harsoulis P, Kuku SF, Marshall JC, Kaufman B, Fraser TR. Infusions of hFSH and hLH in normal men. I. Kinetics of human follicle stimulating hormone. Acta Endocrinol (Copenh). 1976 Feb;81 (2):225-33
  • Knobil E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res. 1980;36:53-88
  • Leonard JM, Leach RB, Couture M, Paulsen CA. Plasma and urinary follicle-stimulating hormone levels in oligospermia. J Clin Endocrinol Metab. 1972 Jan;34 (1):209-14
  • Lundy LE, Lee SG, Levy W, Woodruff JD, Wu CH, Abdalla M. The ovulatory cycle. A histologic, thermal, steroid, and gonadotropin correlation. Obstet Gynecol. 1974 Jul;44 (1):14-25
  • Marshall JC. Clinics in endocrinology and metabolism. Investigative procedures. Clin Endocrinol Metab. 1975 Nov;4 (3):545-67
  • Rebar RW, Erickson GF, Yen SS. Idiopathic premature ovarian failure: clinical and endocrine characteristics. Fertil Steril. 1982 Jan;37 (1):35-41
  • Reiter EO, Kulin HE. Suppressed follicle stimulating hormone in men with chorionic gonadotropin secreting testicular tumors. J Clin Endocrinol Metab. 1971 Dec;33 (6):957-61
  • Seth J, Hanning I, Bacon RR, Hunter WM. Progress and problems in immunoassays for serum pituitary gonadotrophins: evidence from the UK external quality assessment schemes, (EQAS) 1980-1988. Clin Chim Acta. 1989 Dec 29;186 (1):67-82
  • Shome B, Parlow AF. Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). J Clin Endocrinol Metab. 1974 Jul;39 (1):199-202
  • Shome B, Parlow AF. Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). J Clin Endocrinol Metab. 1974 Jul;39 (1):203-5
  • Uotila M, Ruoslahti E, Engvall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha-fetoprotein. J Immunol Methods. 1981;42 (1):11-5
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