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Manufactured by BioVendor

Human Arginase Liver Type ELISA (version2)

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:EC 3.5.3.1, L-arginine aminohydrolase, liver-type arginase, type I arginase, Arginase-1, Liver-type arginase, Type I arginase, L-arginine ureahydrolase
  • Species:Human
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Cat. No. Size Price


New RHK386-02R 2x96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma

Sample Requirements

10 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

1.6-100 ng/ml

Limit of Detection

1.6 ng/ml

Intra-assay (Within-Run)

3.5 %

Inter-assay (Run-to-Run)

7.6 %

Summary

Features

The total assay time is 3.5 hours

The kit measures Arginase Liver Type in human Serum and Plasma

Assay format is 96 wells

Components of the kit are provided ready to use or concentrated

Research topic

Asthma and allergic rhinitis, Blood pressure regulation and NO metabolism, Immunology, Oncology, Pulmonary diseases

Summary

Arginase-I (liver-type Arginase, L-arginine ureahydrolase, or L-arginine amidinohydrolase) is an hydrolytic enzyme that converts arginine to ornithine and urea. Ornithine is the precursor for preline, an essential amino acid for collagen synthesis and for poly-amines, key components in cell growth and differentiation. Arginase exists as two forms designated Arginase-I and Arginase-II which are encoded by different genes. Although Arginase-I and Arginase-II have similar enzyme activities, they differ in immunological reactivity. Human Arginase-I (liver-type Arginase) is a 35 kDa protein circulating in blood probably as a homotrimer. Liver-type Arginase is most abundant expressed in mammalian liver, but is also found in non-hepatic tissues, for instance red blood cells, lactating mammalian glands, and the kidney. In addition to its involvement in ammonia detoxification via the urea cycle, Arginase plays a role in other processes, for instance macrophage-mediated cytotoxicity due to Arginase release and inhibition of lymphocyte proliferation in vitro. It shows high activity in growing tissues, wound healing, proliferating lymphocytes and tumors. Furthermore, Arginase acts as a modulator of the immune response. Besides this Arginase plays a role in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury.

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