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Manufactured by BioVendor

Human Beta 2-microglobulin ELISA, High Sensitive

  • Regulatory status:RUO
  • Type:Sandwich ELISA
  • Species:Human
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Cat. No. Size Price

New RBL014R 96 wells (1 kit)
PubMed Product Details
Technical Data


Sandwich ELISA


Serum, Urine, Plasma

Sample Requirements

1 µl/well


Shipped on blue ice packs. Upon receipt, store the product at the temperature recommended below.


Store the complete kit at 2–8°C. Under these conditions, all components are stable until the expiration date (see label on the box).

Calibration Range

1.25 - 40 ng/ml

Limit of Detection

0.4 ng/ml

Intra-assay (Within-Run)

n = 8
CV = 5.5%

Inter-assay (Run-to-Run)

n = 8
CV = 8.0%

Spiking Recovery


Dilution Linearity




It is intended for research use only

The total assay time is less than 3.5 hours

The kit measures beta 2-microglobulin

Assay format is 96 wells

Quality Controls are human serum based

Standard is a recombinant protein

Components of the kit are provided ready to use, concentrated or dried

Research topic

Oncology, Renal disease


Urinary excretion of Beta 2-microglobulin (beta 2M) is a widely used test of renal proximal tubular function. Proximal tubular dysfunction leads to an increased urinary concentration. The serum level of beta 2-microglobulin is determined by the glomerular filtration rate and the rate of synthesis. Increased production, with raised serum levels, is sometimes observed in malignancy, mainly at an advanced state. A strong correlation between lupus nephritis (LN), disease activity, and serum beta 2-microglobulin (b2MG) was observed. Serum b2MG level can be used as a valuable predictor for LN, clinical disease activity, and damage score.

Summary References (18)

References to Beta2-Microglobulin

  • Bhalla RB, Safai B, Mertelsmann R, Schwartz MK. Abnormally high concentrations of beta 2 microglobulin in acquired immunodeficiency syndrome (AIDS) patients. Clin Chem. 1983 Aug;29 (8):1560
  • Brodsky FM, Bodmer WF, Parham P. Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol. 1979 Jul;9 (7):536-45
  • Burnett RW. Accurate estimation of standard deviations for quantitative methods used in clinical chemistry. Clin Chem. 1975 Dec;21 (13):1935-8
  • Check JH, Ubelacker L, Lauer CC. Falsely elevated steroidal assay levels related to heterophile antibodies against various animal species. Gynecol Obstet Invest. 1995;40 (2):139-40
  • Check JH, Ubelacker L, Lauer CC. Falsely elevated steroidal assay levels related to heterophile antibodies against various animal species. Gynecol Obstet Invest. 1995;40 (2):139-40
  • Domingo P, Martinez E, Martinez C, Fuster M, Cortes M, Sambeat MA, Ris J, Cadafalch J. Prognostic value of serum beta 2-microglobulin in HIV infection. Lancet. 1992 Aug 8;340 (8815):371-2
  • Evrin PE, Jansson NO, Bergdahl A. A turbidimetric immunochemical method for determination of serum beta 2-microglobulin using a centrifugal analyzer. Clin Chim Acta. 1986 Mar 16;155 (2):151-7
  • Fahey JL, Taylor JM, Detels R, Hofmann B, Melmed R, Nishanian P, Giorgi JV. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med. 1990 Jan 18;322 (3):166-72
  • Francioli P, Clement F, Vaudois CH. Beta 2-microglobulin and immunodeficiency in a homosexual man. N Engl J Med. 1982 Nov 25;307 (22):1402-3
  • Lacey JN, Forbes MA, Waugh MA, Cooper EH, Hambling MH. Serum beta 2-microglobulin and human immunodeficiency virus infection. AIDS. 1987 Jul;1 (2):123-7
  • LeClair K, Van Agthoven A, Terhorst C. A rapid method for isolation of antigenically active human cell surface antigens associated with beta 2-microglobulin using a monoclonal antibody. J Immunol Methods. 1981;41 (2):137-44
  • Ling TG, Mattiasson B. A general study of the binding and separation in partition affinity ligand assay. Immunoassay of beta 2-microglobulin. J Immunol Methods. 1983 May 13;59 (3):327-37
  • Nilsson K, Evrin PE, Berggard I, Ponten J. Involvement of lymphoid and nonlymphoid cells in the production of beta2-microglobulin-a homologue of the constant domains of IgG. Nat New Biol. 1973 Jul 11;244 (132):44-5
  • O'Reilly D, Whicher J, Sanderson AR. A simple, precise and sensitive nephelometric assay for beta 2-microglobulin in body fluids. J Immunol Methods. 1983 Feb 25;57 (1-3):265-73
  • Sonnerborg AB, von Stedingk LV, Hansson LO, Strannegard OO. Elevated neopterin and beta 2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection. AIDS. 1989 May;3 (5):277-83
  • Tachibana K, Tanaka E, Usuda S, Okamoto H, Imai M, Nakamura T, Miyakawa Y, Mayumi M. A two-site sandwich radioimmunoassay of beta 2-microglobulin with monoclonal antibodies. J Immunol Methods. 1984 Dec 14;75 (1):43-51
  • Uotila M, Ruoslahti E, Engvall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha-fetoprotein. J Immunol Methods. 1981;42 (1):11-5
  • Wibell L, Evrin PE, Berggard I. Serum 2 -microglobulin in renal disease. Nephron. 1973;10 (5):320-31
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