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Manufactured by BioVendor

Resistin Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RETN, FIZZ3, HXCP1, RSTN, UNQ407/PRO1199
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price

RD191016100 96 wells (1 kit)
PubMed Product Details
Technical Data


Sandwich ELISA, Biotin-labelled antibody


Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

35 µl/well


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1–50 ng/ml

Limit of Detection

0.012 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 5.9%

Inter-assay (Run-to-Run)

n = 5; CV = 7.6%

Spiking Recovery


Dilutation Linearity



  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Yes (recommended dilution 1:6)
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
  • monkey Yes (recommended dilution 1:3)
  • mouse Yes (recommended dilution 1:3)
  • pig Yes (recommended dilution 1:3)


  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 4 hours
  • The kit measures total resistin in serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standard is recombinant protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation


Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteinerich
secreted proteins which is termed the RELM family, and is also described as ADSF
(Adipose Tissue-Specific Secretory Factor) or FIZZ3 (Found in Inflammatory Zone). Human
resistin contains 108 amino acids as a prepeptide, and its hydrophobic signal peptide is
cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting
of two 92 amino acid polypeptides, which are disulfide-linked via Cys26.

Much of the early investigations about the resistin molecule are based on the mouse model.
Resistin, produced and secreted primarily by adipocytes in mice, acts on skeletal muscle
myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin.
Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate
glucose uptake. Other studies have shown that mouse resistin increases during the
differentiation of adipocytes, but it also seems to inhibit adipogenesis.

Compared to the mouse model, human adipogenic differentiation is likely to be associated with
a down regulation of resistin gene expression. On the other hand, resistin was found to be
expressed at high levels in human monocytes, macrophages and bone marrow.
Recent investigations have shown that human resistin is correlated with metabolic syndrome
and obesity-related disorders. Malo et al. have reported that resistin levels are positively
associated with waist circumference, tumor necrosis factor-a, and insulin resistance assessed
by the homeostasis model, and inversely correlated with total cholesterol, HDL cholesterol, and
LDL cholesterol. Moreover, Sadhasiv et al. found a positive correlation of SAT (subcutaneous
adipose tissue) resistin mRNA expression with serum resistin, BMI and insulin resistance
(HOMA index).

Based on the above reports human resistin might be an important marker that acts as the link
between obesity and insulin resistance. Resistin can play a role also in inflammation processes
and in atherosclerosis.
Clinical use and areas of investigation: Energy metabolism and body weight regulation, Metabolic syndrome, Inflammation, Atherosclerosis

References to Product


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  • Hulejova H, Levitova A, Kuklova M, Stochl J, Haluzik M, Pavelka K, Vencovsky J, Senolt L. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol. 2011 May 28;
  • Iacobellis G, Petramala L, Cotesta D, Pergolini M, Zinnamosca L, Cianci R, De Toma G, Sciomer S, Letizia C. Adipokines and cardiometabolic profile in primary hyperaldosteronism. J Clin Endocrinol Metab. 2010 May;95 (5):2391-8
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  • Jorgensen SB, Honeyman J, Oakhill JS, Fazakerley D, Stockli J, Kemp BE, Steinberg GR. Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation. Am J Physiol Endocrinol Metab. 2009 Jul;297 (1):E57-66
  • Jurcovicova J, Stofkova A, Skurlova M, Baculikova M, Zorad S, Stancikova M. Alterations in adipocyte glucose transporter GLUT4 and circulating adiponectin and visfatin in rat adjuvant induced arthritis. Gen Physiol Biophys. 2010 Mar;29 (1):79-84
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  • Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care . Mar;30(3):719-21 (2007)
  • Kakizaki S, Sohara N, Yamazaki Y, Horiguchi N, Kanda D, Kabeya K, Katakai K, Sato K, Takagi H, Mori M. Elevated plasma resistin concentrations in patients with liver cirrhosis. J Gastroenterol Hepatol. 2008 Jan;23 (1):73-7
  • Kassem E, Mahmoud L, Salah W. Study of Resistin and YKL-40 in Rheumatoid Arthritis. Journal of American Science. 2010;6(10):1004-1012;
  • Kielstein JT, Becker B, Graf S, Brabant G, Haller H, Fliser D. Increased resistin blood levels are not associated with insulin resistance in patients with renal disease. Am J Kidney Dis . Jul;42(1):62-6 (2003)
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References to Summary

References to Resistin

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