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Serum Pre-Clinical CartiLaps® ELISA (CTX-II)

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:C-terminal telopeptide II, carboxy-terminal collagen II crosslinks
  • Species:Animal
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Cat. No. Size Price


AC-08F1 96 wells
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Description

The Serum Pre-Clinical CartiLaps® (CTX-II) ELISA detects degradation products of C-terminal telopeptides of type II collagen (CTX-II) in animal serum. The test is intended for research use only, not for use in diagnostic procedures.

Scientific Description:

Disruption of the structural integrity of cartilage is the major histological finding in osteoarthritis and rheumatoid arthritis. Type II collagen is the major organic constituent of cartilage and fragments of type II collagen (CTX-II) are being released into circulation and subsequently secreted into urine following degradation of cartilage. In non-human serum, the CTX-II fragments can be quantified by Serum Pre-Clinical CartiLaps®(CTX-II) ELISA. The Serum Pre-Clinical CartiLaps® (CTX-II) ELISA has been reported to be useful for rat, mice, rabbit, dog, guinea pig and cynomolgus monkey and horse specimens.

Applications

Cartilage Explant Culture Supernatant and Synovial Fluid, Serum, Plasma

Sample Requirements

25 µL/well

Storage/Expiration

Store the complete kit at 2-8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0-300 pg/mL

Limit of Detection

3.7 pg/mL

Summary

Features

  • Animal Models of Rheumatoid Arthritis and Osteoarthritis
  • Easy, non-invasive quantification of cartilage degradation
  • Strong association to indexes of joint damage, e.g. cartilage erosion
  • Demonstration of Chondroprotective Effect of Drugs
  • Rapid response to chondroprotective drugs (within 1-2 weeks)
  • Early response in CTX-II is highly correlated to histological endpoints
  • CTX-II can be quantified in relevant cartilage explant culture supernatant human origin and animal models
  • CTX-II is elevated in both RA and OA rat models
  • CTX-II levels are associated with disease activity in RA and OA, primarily indexes of structural damage
  • Useful for dynamic monitoring of cartilage in multiple species

Research topic

Bone and cartilage metabolism

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