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Manufactured by BioVendor

sHLA-G ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:soluble HLA-G
  • Species:Human
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Cat. No. Size Price


RD194070100R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Plasma-EDTA, Amniotic fluid, Cell culture supernatant

Sample Requirements

25 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

3.91–125 Units/ml

Limit of Detection

0.6 Units/ml

Intra-assay (Within-Run)

n = 8; CV = 4.2%

Inter-assay (Run-to-Run)

n = 11; CV = 7.0%

Spiking Recovery

91,20%

Dilution Linearity

99,40%

Summary

Features

  • It is intended for research use only
  • The total assay time is about 20 hours
  • The kit measures shedded HLA-G1 and HLA-G5 in EDTA plasma, amniotic fluid, or cell culture supernatant
  • Calibrator is human native protein
  • Assay format is 96 wells
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Immune Response, Infection and Inflammation, Reproduction, Transplantation

Summary

HLA-G differs from the other MHC class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. Soluble HLA-G is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Recently, using specific ELISA to analyse the presence of sHLA-G molecules in culture supernatants of early embryos obtained by in vitro fertilization (IVF) before transfer, several reports demonstrated that positive embryo implantations occurred with embryo secreting sHLA-G molecules. These breakthrough results indicate that sHLA-G ELISA can be a useful biochemical assay in addition to embryo morphology in embryo selection for transfer in IVF treatment if there are other embryos with the same morphology. Furthermore, monitoring of sHLA-G in amniotic fluid and plasma of pregnant women may have an important prognostic value to recognize pathological situations. Other interesting observations suggest that HLA-G molecules seem to be directly involved in transplant acceptation, and their analysis should be taken into consideration when monitoring transplant-patients status. In addition, soluble HLA-G plasma levels are increased in lyphoproliferative disorders or in patients suffering from malignant melanoma, glioma, breast and ovarian cancer.

Product References (48)

References

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  • McCormick J, Whitley GS, Le Bouteiller P, Cartwright JE. Soluble HLA-G regulates motility and invasion of the trophoblast-derived cell line SGHPL-4. Hum Reprod. 2009 Jun;24(6):1339-45. doi: 10.1093/humrep/dep026. Epub 2009 Feb 16. PubMed PMID: 19223288. See more on PubMed
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  • Coulam CB, Roussev RG, Lerner S, Zlatopolsky Z, Ilkevitch Y, Tur-Kaspa I. How to predict implantation? No correlation between embryonic aneuploidy and soluble human leukocyte antigen G-concentrations. Fertil Steril. 2009 Jun;91(6):2408-13. doi: 10.1016/j.fertnstert.2008.03.081. Epub 2009 Apr 25. PubMed PMID: 19394602. See more on PubMed
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  • Chen XY, Yan WH, Lin A, Xu HH, Zhang JG, Wang XX. The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma. Tissue Antigens. 2008 Oct;72(4):335-41. doi: 10.1111/j.1399-0039.2008.01107.x. Epub 2008 Aug 12. PubMed PMID: 18700878. See more on PubMed
  • Giannopoulos K, Schmitt M, Kowal M, Własiuk P, Bojarska-Junak A, Roliński J, Dmoszyńska A. The significance of soluble HLA-G plasma levels as well as messenger HLA-G for B-cell chronic lymphocytic leukemia (B-CLL). Leuk Res. 2008 Dec;32(12):1815-9. doi: 10.1016/j.leukres.2008.04.008. Epub 2008 May 21. PubMed PMID: 18499249. See more on PubMed
  • Wang F, Wen Z, Li H, Yang Z, Zhao X, Yao X. Human leukocyte antigen-G is expressed by the eutopic and ectopic endometrium of adenomyosis. Fertil Steril. 2008 Nov;90(5):1599-604. doi: 10.1016/j.fertnstert.2007.06.073. Epub 2007 Oct 22. PubMed PMID: 17953947. See more on PubMed
  • Ciprandi G, Colombo BM, Contini P, Cagnati P, Pistorio A, Puppo F, Murdaca G. Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis. Allergy. 2008 Oct;63(10):1335-8. doi: 10.1111/j.1398-9995.2008.01741.x. PubMed PMID: 18782112. See more on PubMed
  • Dunker K, Schlaf G, Bukur J, Altermann WW, Handke D, Seliger B. Expression and regulation of non-classical HLA-G in renal cell carcinoma. Tissue Antigens. 2008 Aug;72(2):137-48. doi: 10.1111/j.1399-0039.2008.01090.x. PubMed PMID: 18721274. See more on PubMed
  • Shaikly VR, Morrison IE, Taranissi M, Noble CV, Withey AD, Cherry RJ, Blois SM, Fernández N. Analysis of HLA-G in maternal plasma, follicular fluid, and preimplantation embryos reveal an asymmetric pattern of expression. J Immunol. 2008 Mar 15;180(6):4330-7. doi: 10.4049/jimmunol.180.6.4330. PubMed PMID: 18322247. See more on PubMed
  • Le Maux A, Noël G, Birebent B, Grosset JM, Vu N, De Guibert S, Bernard M, Semana G, Amiot L. Soluble human leucocyte antigen-G molecules in peripheral blood haematopoietic stem cell transplantation: a specific role to prevent acute graft-versus-host disease and a link with regulatory T cells. Clin Exp Immunol. 2008 Apr;152(1):50-6. doi: 10.1111/j.1365-2249.2008.03598.x. Epub 2008 Jan 28. PubMed PMID: 18241225. PubMed CentralPMCID: PMC2384077. See more on PubMed
  • Eidukaite A, Tamosiunas V. Soluble HLA-G in the peritoneal fluid of women with endometriosis. Fertil Steril. 2008 Feb;89(2):465-7. doi: 10.1016/j.fertnstert.2007.02.036. Epub 2007 May 16. PubMed PMID: 17509578. See more on PubMed
  • Steinborn A, Varkonyi T, Scharf A, Bahlmann F, Klee A, Sohn C. Early detection of decreased soluble HLA-G levels in the maternal circulation predicts the occurrence of preeclampsia and intrauterine growth retardation during further course of pregnancy. Am J Reprod Immunol. 2007 Apr;57(4):277-86. doi: 10.1111/j.1600-0897.2007.00475.x. PubMed PMID: 17362389. See more on PubMed
  • Desai N, Filipovits J, Goldfarb J. Secretion of soluble HLA-G by day 3 human embryos associated with higher pregnancy and implantation rates: assay of culture media using a new ELISA kit. Reprod Biomed Online. 2006 Aug;13(2):272-7. doi: 10.1016/s1472-6483(10)60626-8. PubMed PMID: 16895646. See more on PubMed
  • Tahan F, Patiroglu T. Plasma soluble human leukocyte antigen G levels in asthmatic children. Int Arch Allergy Immunol. 2006;141(3):213-6. doi: 10.1159/000095290. Epub 2006 Aug 22. PubMed PMID: 16926540. See more on PubMed
  • Wiendl H, Feger U, Mittelbronn M, Jack C, Schreiner B, Stadelmann C, Antel J, Brueck W, Meyermann R, Bar-Or A, Kieseier BC, Weller M. Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. Brain. 2005 Nov;128(Pt 11):2689-704. doi: 10.1093/brain/awh609. Epub 2005 Aug 25. PubMed PMID: 16123145. See more on PubMed
  • Wiendl H, Mitsdoerffer M, Hofmeister V, Wischhusen J, Bornemann A, Meyermann R, Weiss EH, Melms A, Weller M. A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol. 2002 May 1;168(9):4772-80. doi: 10.4049/jimmunol.168.9.4772. PubMed PMID: 11971028. See more on PubMed
Summary References (20)

References to HLA-G

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  • Le Bouteiller P., Pizzato N., Barakonyi A., Solier C.: HLA-G, pre-eclampsia, immunity and vascular events. J Reprod Immunol. 2003; 59: 219–234
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