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Soluble Receptor for Advanced Glycation End Products (sRAGE) Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:Soluble Receptor for Advanced Glycation End Products, sRAGE, Advanced glycation end product-specific receptor, AGER, RAGE
  • Species:Human
Cat. No. Size Price

RD191116200R 96 wells (1 kit) $531
PubMed Product Details
Technical Data


Sandwich ELISA, Biotin-labelled antibody


Serum, Plasma

Sample Requirements

50 μl/well


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

50–3200 pg/ml

Limit of Detection

19.2 pg/ml

Intra-assay (Within-Run)

n = 8; CV = 4.0%

Inter-assay (Run-to-Run)

n = 6; CV = 7.2%

Spiking Recovery


Dilution Linearity



  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes


  • It is intended for research use only.
  • The total assay time is less than 3.5 hours.
  • The kit measures sRAGE in serum and plasma (EDTA, citrate, heparin).
  • Assay format is 96 wells.
  • Standard is recombinant protein based
  • Quality Controls are human serum based. No animal sera are used.
  • Components of the kit are provided ready to use, concentrated or lyophilized.

Research topic

Diabetology - Other Relevant Products, Neural tissue markers, Pulmonary diseases, Renal disease


The receptor for advanced glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules. It mediates interactions of advanced glycation end products (AGE), the products of nonenzymatic glycoxidation of proteins/lipids that accumulate in the plasma and tissues of patients with diabetes.

Product References (9)


  • Miłkowska-Dymanowska J, Białas AJ, Szewczyk K, Kurmanowska Z, Górski P, Piotrowski WJ. The usefulness of soluble receptor for advanced glycation end-products in the identification of COPD frequent exacerbator phenotype. Int J Chron Obstruct Pulmon Dis. 2018 Nov 29;13:3879-3884. doi: 10.2147/COPD.S186170. eCollection 2018. PubMed PMID: 30568439. PubMed CentralPMCID: PMC6276626. See more on PubMed
  • Labib JR, Ibrahem SK, Sleem HM, Ismail MM, Abd El Fatah SAM, Salem MR, Abdelaal AA, Al-Hanafi H. Diagnostic indicator of acute lung injury for pediatric critically ill patients at a tertiary pediatric hospital. Medicine (Baltimore). 2018 Mar;97(10):e9929. doi: 10.1097/MD.0000000000009929. PubMed PMID: 29517700. PubMed CentralPMCID: PMC5882441. See more on PubMed
  • Traore K, Thera MA, Bienvenu AL, Arama C, Bonnot G, Lavoignat A, Doumbo OK, Picot S. Interaction between environment, nutrient-derived metabolites and immunity: A possible role in malaria susceptibility/resistance in Fulani and Dogon of Mali. PLoS One. 2017 Dec 20;12(12):e0189724. doi: 10.1371/journal.pone.0189724. eCollection 2017. PubMed PMID: 29261755. PubMed CentralPMCID: PMC5738089. See more on PubMed
  • Klein R, Horak K, Lee KE, Danforth L, Cruickshanks KJ, Tsai MY, Gangnon RE, Klein BEK. The Relationship of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE) and Carboxymethyl Lysine (CML) to the Incidence of Diabetic Nephropathy in Persons With Type 1 Diabetes. Diabetes Care. 2017 Sep;40(9):e117-e119. doi: 10.2337/dc17-0421. Epub 2017 Jun 19. PubMed PMID: 28630056. PubMed CentralPMCID: PMC5566284. See more on PubMed
  • Rzepka R, Dołegowska B, Rajewska A, Kwiatkowski S, Sałata D, Budkowska M, Domański L, Mikołajek-Bedner W, Torbé A. Soluble and Endogenous Secretory Receptors for Advanced Glycation End Products in Threatened Preterm Labor and Preterm Premature Rupture of Fetal Membranes. Biomed Res Int. 2015;2015:568042. doi: 10.1155/2015/568042. Epub 2015 Aug 27. PubMed PMID: 26413536. PubMed CentralPMCID: PMC4564602. See more on PubMed
  • Davis KE, Prasad C, Vijayagopal P, Juma S, Imrhan V. Serum soluble receptor for advanced glycation end products correlates inversely with measures of adiposity in young adults. Nutr Res. 2014 Jun;34(6):478-85. doi: 10.1016/j.nutres.2014.04.012. Epub 2014 Apr 24. PubMed PMID: 25026914. See more on PubMed
  • Ng ZX, Kuppusamy UR, Iqbal T, Chua KH. Receptor for advanced glycation end-product (RAGE) gene polymorphism 2245G/A is associated with pro-inflammatory, oxidative-glycation markers and sRAGE in diabetic retinopathy. Gene. 2013 Jun 1;521(2):227-33. doi: 10.1016/j.gene.2013.03.062. Epub 2013 Mar 29. PubMed PMID: 23545311. See more on PubMed
  • Asgeirsson T, Zhang S, Khoo SK, Resau JH, Dujovny N, Senagore AJ. Serum adiponectin, resistin, and circulating soluble receptor for advanced glycation end products in colectomy patients. Mediators Inflamm. 2011;2011:916807. doi: 10.1155/2011/916807. Epub 2011 Sep 7. PubMed PMID: 21912448. PubMed CentralPMCID: PMC3168899. See more on PubMed
  • Kwon JH, Kim YH, Kwon JY, Park YW. Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia. J Perinat Med. 2011 Sep;39(5):507-13. doi: 10.1515/jpm.2011.055. Epub 2011 Jul 18. PubMed PMID: 21767223. See more on PubMed
Summary References (12)

References to Soluble Receptor for Advanced Glycation End Products (sRAGE)

  • Brett J, Schmidt AM, Yan SD, Zou YS, Weidman E, Pinsky D, Nowygrod R, Neeper M, Przysiecki C, Shaw A, et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol. 1993 Dec;143 (6):1699-712
  • Emanuele E, D'Angelo A, Tomaino C, Binetti G, Ghidoni R, Politi P, Bernardi L, Maletta R, Bruni AC, Geroldi D. Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia. Arch Neurol. 2005 Nov;62 (11):1734-6
  • Falcone C, Emanuele E, D'Angelo A, Buzzi MP, Belvito C, Cuccia M, Geroldi D. Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men. Arterioscler Thromb Vasc Biol. 2005 May;25 (5):1032-7
  • Geroldi D, Falcone C, Emanuele E. Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target. Curr Med Chem. 2006;13 (17):1971-8
  • Ghidoni R, Benussi L, Glionna M, Franzoni M, Geroldi D, Emanuele E, Binetti G. Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment. J Neural Transm. 2008 Jul;115 (7):1047-50
  • Goh SY, Cooper ME. Clinical review: The role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 2008 Apr;93 (4):1143-52
  • Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006 Aug 8;114 (6):597-605
  • Gugliucci A. Glycation as the glucose link to diabetic complications. J Am Osteopath Assoc. 2000 Oct;100 (10):621-34
  • Hudson BI, Harja E, Moser B, Schmidt AM. Soluble levels of receptor for advanced glycation endproducts (sRAGE) and coronary artery disease: the next C-reactive protein?. Arterioscler Thromb Vasc Biol. 2005 May;25 (5):879-82
  • Kalousova M, Hodkova M, Kazderova M, Fialova J, Tesar V, Dusilova-Sulkova S, Zima T. Soluble receptor for advanced glycation end products in patients with decreased renal function. Am J Kidney Dis. 2006 Mar;47 (3):406-11
  • Pullerits R, Bokarewa M, Dahlberg L, Tarkowski A. Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control. Arthritis Res Ther. 2005;7 (4):R817-24
  • Schmidt AM, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, Esposito C, Hegarty H, Hurley W, Clauss M, et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem. 1992 Jul 25;267 (21):14987-97
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