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Adiponectin Human ELISA, High Sensitivity (Sandwich)

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Adipocyte C1q and collagen domain-containing protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ADIPOQ, ACDC, APM1, GBP28
  • Species:Human
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Cat. No. Size Price


RD191023100 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Urine, Cerebrospinal fluid, Milk, Plasma

Sample Requirements

10 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, assay components are stable till the expiry date is over. (See the expiry date indicated on the kit label).

Calibration Curve

Limit of Detection

serum or plasma samples: 0.47 ng/ml
milk, CSF or urine: 0.156 ng/ml

Intra-assay (Within-Run)

n=8 CV = 3.9%

Inter-assay (Run-to-Run)

n=8 CV = 6.0%

Spiking Recovery

90.5%

Crossreactivity

  • bovine Non-detectable
  • cat Yes (recommended dilution 1:60)
  • goat Non-detectable
  • horse Non-detectable
  • dog Yes (recommended dilution 1:120)
  • hamster Yes (recommended dilution 1:120)
  • pig Non-detectable
  • rabbit Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
  • rat Yes (recommended dilution 1:60)
  • monkey Yes (recommended dilution 1:600)
  • mouse None-specific binding
Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 3 hours
  • The kit measures total adiponectin in serum, plasma (EDTA, citrate, heparin), urine, cerebrospinal fluid (CSF), and breast milk
  • Assay format is 96 wells
  • Quality Controls are human serum based. No animal sera are used
  • Standards are recombinant adiponectin based
  • Components of the kit are provided ready to use or concentrated

Research topic

Chronic renal failure, Coronary artery disease, Diabetology - Other Relevant Products, Energy metabolism and body weight regulation

Summary

Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01% of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned; AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury and also stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. Altogether, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.

Product References (93)

References

  • Ahn SY, Kim DK, Han SS, Park JH, Shin SJ, Lee SH, Choi BS, Lim CS, Kim S, ChinHJ. Weight loss has an additive effect on the proteinuria reduction ofangiotensin II receptor blockers in hypertensive patients with chronic kidneydisease. Kidney Res Clin Pract. 2018 Mar;37(1):49-58. doi:10.23876/j.krcp.2018.37.1.49. Epub 2018 Mar 31. PubMed PMID: 29629277; PubMedCentral PMCID: PMC5875576. See more on PubMed
  • Ajabnoor GM, Bahijri S, Shaik NA, Borai A, Alamoudi AA, Al-Aama JY, ChrousosGP. Ramadan fasting in Saudi Arabia is associated with altered expression ofCLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic riskfactors. PLoS One. 2017 Apr 6;12(4):e0174342. doi: 10.1371/journal.pone.0174342. eCollection 2017. PubMed PMID: 28384165; PubMed Central PMCID: PMC5401765. See more on PubMed
  • Asgeirsson T, Zhang S, Khoo SK, Resau JH, Dujovny N, Senagore AJ. Serumadiponectin, resistin, and circulating soluble receptor for advanced glycationend products in colectomy patients. Mediators Inflamm. 2011;2011:916807. doi:10.1155/2011/916807. Epub 2011 Sep 7. PubMed PMID: 21912448; PubMed CentralPMCID: PMC3168899. See more on PubMed
  • Avignon A, Sultan A, Piot C, Mariano-Goulart D, Thuan Dit Dieudonné JF,Cristol JP, Dupuy AM. Osteoprotegerin: a novel independent marker for silentmyocardial ischemia in asymptomatic diabetic patients. Diabetes Care. 2007Nov;30(11):2934-9. Epub 2007 Aug 21. PubMed PMID: 17712025. See more on PubMed
  • Bahijri SM, Ajabnoor G, Hegazy GA, Alsheikh L, Moumena MZ, Bashanfar BM,Alzahrani AH. Supplementation with Oligonol, Prevents Weight Gain and ImprovesLipid Profile in Overweight and Obese Saudi Females. Curr Nutr Food Sci. 2018Apr;14(2):164-170. doi: 10.2174/1573401313666170609101408. PubMed PMID: 29853817;PubMed Central PMCID: PMC5907059. See more on PubMed
  • Baranova A, Gowder SJ, Schlauch K, Elariny H, Collantes R, Afendy A, Ong JP,Goodman Z, Chandhoke V, Younossi ZM. Gene expression of leptin, resistin, andadiponectin in the white adipose tissue of obese patients with non-alcoholicfatty liver disease and insulin resistance. Obes Surg. 2006 Sep;16(9):1118-25.PubMed PMID: 16989692. See more on PubMed
  • Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivityof men and women to anorexigenic and memory-improving effects of intranasalinsulin. J Clin Endocrinol Metab. 2008 Apr;93(4):1339-44. doi:10.1210/jc.2007-2606. Epub 2008 Jan 29. PubMed PMID: 18230654. See more on PubMed
  • Bjornvad CR, Rand JS, Tan HY, Jensen KS, Rose FJ, Armstrong PJ, Whitehead JP. Obesity and sex influence insulin resistance and total and multimer adiponectinlevels in adult neutered domestic shorthair client-owned cats. Domest AnimEndocrinol. 2014 Apr;47:55-64. doi: 10.1016/j.domaniend.2013.11.006. Epub 2013Dec 5. PubMed PMID: 24373250. See more on PubMed
  • Bobbert T, Wegewitz U, Brechtel L, Freudenberg M, Mai K, Möhlig M, DiederichS, Ristow M, Rochlitz H, Pfeiffer AF, Spranger J. Adiponectin oligomers in human serum during acute and chronic exercise: relation to lipid metabolism and insulinsensitivity. Int J Sports Med. 2007 Jan;28(1):1-8. Epub 2006 Nov 28. PubMed PMID:17133288. See more on PubMed
  • Boura P, Grapsa D, Loukides S, Angelidou M, Tsakanika K, Syrigos N, Gkiozos I.The prognostic value of serum and bronchoalveolar lavage levels of adiponectin inadvanced non-small-cell lung cancer. Lung Cancer Manag. 2017 Nov;6(2):55-65. doi:10.2217/lmt-2016-0018. Epub 2017 Nov 17. PubMed PMID: 30643571; PubMed CentralPMCID: PMC6310335. See more on PubMed
  • Bronsky J, Karpísek M, Bronská E, Pechová M, Jancíková B, Kotolová H, StejskalD, Prusa R, Nevoral J. Adiponectin, adipocyte fatty acid binding protein, andepidermal fatty acid binding protein: proteins newly identified in human breastmilk. Clin Chem. 2006 Sep;52(9):1763-70. Epub 2006 Jul 27. PubMed PMID: 16873294. See more on PubMed
  • Bronsky J, Mitrova K, Karpisek M, Mazoch J, Durilova M, Fisarkova B, Stechova K, Prusa R, Nevoral J. Adiponectin, AFABP, and leptin in human breast milk during12 months of lactation. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):474-7. doi: 10.1097/MPG.0b013e3182062fcc. PubMed PMID: 21407103. See more on PubMed
  • Bužga M, Evžen M, Pavel K, Tomáš K, Vladislava Z, Pavel Z, Svagera Z. Effects of the intragastric balloon MedSil on weight loss, fat tissue, lipid metabolism, and hormones involved in energy balance. Obes Surg. 2014 Jun;24(6):909-15. doi:10.1007/s11695-014-1191-4. PubMed PMID: 24488758; PubMed Central PMCID:PMC4022986. See more on PubMed
  • Cabré A, Lázaro I, Girona J, Manzanares J, Marimón F, Plana N, Heras M, MasanaL. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction andcardiovascular disease in type 2 diabetes. J Intern Med. 2007 Oct;262(4):496-503.PubMed PMID: 17875187. See more on PubMed
  • Cabré A, Lázaro I, Girona J, Manzanares JM, Marimón F, Plana N, Guardiola M,Heras M, Masana L. The APOA5-1131 T>C variant enhances the association betweenRBP4 and hypertriglyceridemia in diabetes. Nutr Metab Cardiovasc Dis. 2010May;20(4):243-8. doi: 10.1016/j.numecd.2009.04.003. Epub 2009 Sep 17. PubMedPMID: 19765959. See more on PubMed
  • Capel F, Klimcáková E, Viguerie N, Roussel B, Vítková M, Kováciková M, PolákJ, Kovácová Z, Galitzky J, Maoret JJ, Hanácek J, Pers TH, Bouloumié A, Stich V,Langin D. Macrophages and adipocytes in human obesity: adipose tissue geneexpression and insulin sensitivity during calorie restriction and weightstabilization. Diabetes. 2009 Jul;58(7):1558-67. doi: 10.2337/db09-0033. Epub2009 Apr 28. PubMed PMID: 19401422; PubMed Central PMCID: PMC2699855. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Pastor C, Rotellar F, Silva C, Rodríguez A, GilMJ, Cienfuegos JA, Salvador J, Vendrell J, Frühbeck G. Influence of morbidobesity and insulin resistance on gene expression levels of AQP7 in visceraladipose tissue and AQP9 in liver. Obes Surg. 2008 Jun;18(6):695-701. doi:10.1007/s11695-008-9453-7. Epub 2008 Apr 10. PubMed PMID: 18401671. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Ramirez B, Rotellar F, Pastor C, Silva C,Rodríguez A, Gil MJ, Cienfuegos JA, Frühbeck G. Proinflammatory cytokines inobesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg. 2007Nov;17(11):1464-74. PubMed PMID: 18219773. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Rodríguez A, Silva C, Rotellar F, Gil MJ,Cienfuegos JA, Salvador J, Frühbeck G. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin Endocrinol (Oxf). 2008 Feb;68(2):213-9. Epub2007 Sep 4. PubMed PMID: 17803693. See more on PubMed
  • Corpeleijn E, Feskens EJ, Jansen EH, Mensink M, Saris WH, Blaak EE. Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes:the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht(SLIM). Diabetes Care. 2007 Dec;30(12):3125-7. Epub 2007 Sep 21. PubMed PMID:17890316. See more on PubMed
  • Dieplinger B, Gegenhuber A, Haltmayer M, Mueller T. Evaluation of novelbiomarkers for the diagnosis of acute destabilised heart failure in patients withshortness of breath. Heart. 2009 Sep;95(18):1508-13. doi:10.1136/hrt.2009.170696. Epub 2009 Jun 11. PubMed PMID: 19525245. See more on PubMed
  • Dieplinger B, Gegenhuber A, Kaar G, Poelz W, Haltmayer M, Mueller T.Prognostic value of established and novel biomarkers in patients with shortnessof breath attending an emergency department. Clin Biochem. 2010 Jun;43(9):714-9. doi: 10.1016/j.clinbiochem.2010.02.002. Epub 2010 Feb 11. PubMed PMID: 20153308. See more on PubMed
  • Dieplinger B, Gegenhuber A, Poelz W, Haltmayer M, Mueller T. Prognostic value of increased adiponectin plasma concentrations in patients with acutedestabilized heart failure. Clin Biochem. 2009 Jul;42(10-11):1190-3. doi:10.1016/j.clinbiochem.2009.02.023. Epub 2009 Mar 6. PubMed PMID: 19272369. See more on PubMed
  • Dieplinger B, Haltmayer M, Poelz W, Mueller T. Value of adiponectin aspredictor of 5-year all-cause mortality in patients with symptomatic peripheralarterial disease: results from the Linz Peripheral Arterial Disease (LIPAD)study. Clin Chim Acta. 2009 Oct;408(1-2):87-91. doi: 10.1016/j.cca.2009.07.014.Epub 2009 Jul 30. PubMed PMID: 19646980. See more on PubMed
  • Drechsler C, Krane V, Winkler K, Dekker FW, Wanner C. Changes in adiponectinand the risk of sudden death, stroke, myocardial infarction, and mortality inhemodialysis patients. Kidney Int. 2009 Sep;76(5):567-75. doi:10.1038/ki.2009.200. Epub 2009 Jun 10. PubMed PMID: 19516245. See more on PubMed
  • Duus K, Pagh RT, Holmskov U, Højrup P, Skov S, Houen G. Interaction ofcalreticulin with CD40 ligand, TRAIL and Fas ligand. Scand J Immunol. 2007Nov;66(5):501-7. PubMed PMID: 17953526. See more on PubMed
  • Efstathiou SP, Tsioulos DI, Tsiakou AG, Gratsias YE, Pefanis AV, MountokalakisTD. Plasma adiponectin levels and five-year survival after first-ever ischemicstroke. Stroke. 2005 Sep;36(9):1915-9. Epub 2005 Aug 18. PubMed PMID: 16109902. See more on PubMed
  • Escoté X, Félix-Soriano E, Gayoso L, Huerta AE, Alvarado MA, Ansorena D,Astiasarán I, Martínez JA, Moreno-Aliaga MJ. Effects of EPA and lipoic acidsupplementation on circulating FGF21 and the fatty acid profile inoverweight/obese women following a hypocaloric diet. Food Funct. 2018 May23;9(5):3028-3036. doi: 10.1039/c8fo00355f. PubMed PMID: 29766165. See more on PubMed
  • Filková M, Lisková M, Hulejová H, Haluzík M, Gatterová J, Pavelková A, PavelkaK, Gay S, Müller-Ladner U, Senolt L. Increased serum adiponectin levels in femalepatients with erosive compared with non-erosive osteoarthritis. Ann Rheum Dis.2009 Feb;68(2):295-6. doi: 10.1136/ard.2008.095737. PubMed PMID: 19139213. See more on PubMed
  • Golledge J, Jayalath R, Oliver L, Parr A, Schurgers L, Clancy P. Relationship between CT anthropometric measurements, adipokines and abdominal aorticcalcification. Atherosclerosis. 2008 Mar;197(1):428-34. Epub 2007 Aug 6. PubMedPMID: 17675038; PubMed Central PMCID: PMC2288671. See more on PubMed
  • Gómez-Ambrosi J, Catalán V, Ramírez B, Rodríguez A, Colina I, Silva C,Rotellar F, Mugueta C, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G. Plasmaosteopontin levels and expression in adipose tissue are increased in obesity. JClin Endocrinol Metab. 2007 Sep;92(9):3719-27. Epub 2007 Jun 26. PubMed PMID:17595250. See more on PubMed
  • Gridneva Z, Kugananthan S, Rea A, Lai CT, Ward LC, Murray K, Hartmann PE,Geddes DT. Human Milk Adiponectin and Leptin and Infant Body Composition over theFirst 12 Months of Lactation. Nutrients. 2018 Aug 20;10(8). pii: E1125. doi:10.3390/nu10081125. PubMed PMID: 30127292; PubMed Central PMCID: PMC6115716. See more on PubMed
  • Haluzíková D, Dostálová I, Kaválková P, Roubícek T, Mráz M, Papezová H,Haluzík M. Serum concentrations of adipocyte fatty acid binding protein inpatients with anorexia nervosa. Physiol Res. 2009;58(4):577-81. Epub 2008 Jul 25.PubMed PMID: 18657008. See more on PubMed
  • Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM. Adipocyte fattyacid-binding protein as a novel prognostic factor in obese breast cancerpatients. Breast Cancer Res Treat. 2010 Jan;119(2):367-7. doi:10.1007/s10549-009-0577-9. PubMed PMID: 19842034. See more on PubMed
  • Hellmuth C, Uhl O, Demmelmair H, Grunewald M, Auricchio R, Castillejo G,Korponay-Szabo IR, Polanco I, Roca M, Vriezinga SL, Werkstetter KJ, Koletzko B,Mearin ML, Kirchberg FF. The impact of human breast milk components on the infantmetabolism. PLoS One. 2018 Jun 1;13(6):e0197713. doi:10.1371/journal.pone.0197713. eCollection 2018. PubMed PMID: 29856767; PubMedCentral PMCID: PMC5983411. See more on PubMed
  • Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring HU, Stefan N.Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One. 2008 Mar 12;3(3):e1765. doi: 10.1371/journal.pone.0001765. PubMed PMID:18335040; PubMed Central PMCID: PMC2258416. See more on PubMed
  • Horakova D, Stepanek L, Nagelova R, Pastucha D, Azeem K, Kollarova H. Totaland high-molecular-weight adiponectin levels and prediction of insulinresistance. Endokrynol Pol. 2018;69(4):375-380. doi: 10.5603/EP.a2018.0035. Epub 2018 Jun 28. PubMed PMID: 29952412. See more on PubMed
  • Hulejová H, Levitová A, Kuklová M, Stochl J, Haluzík M, Pavelka K, VencovskýJ, Senolt L. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol. 2012 Jan;31(1):67-71. doi: 10.1007/s10067-011-1773-7. Epub 2011 May 28. PubMed PMID: 21618078. See more on PubMed
  • Chu MC, Cosper P, Orio F, Carmina E, Lobo RA. Insulin resistance inpostmenopausal women with metabolic syndrome and the measurements of adiponectin,leptin, resistin, and ghrelin. Am J Obstet Gynecol. 2006 Jan;194(1):100-4. PubMedPMID: 16389017. See more on PubMed
  • Iacobellis G, Petramala L, Cotesta D, Pergolini M, Zinnamosca L, Cianci R, De Toma G, Sciomer S, Letizia C. Adipokines and cardiometabolic profile in primaryhyperaldosteronism. J Clin Endocrinol Metab. 2010 May;95(5):2391-8. doi:10.1210/jc.2009-2204. Epub 2010 Mar 1. PubMed PMID: 20194710. See more on PubMed
  • Izaguirre M, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Becerril S, Valentí V,Moncada R, Unamuno X, Silva C, de la Higuera M, Salvador J, Monreal I, FrühbeckG, Catalán V. GLP-1 Limits Adipocyte Inflammation and Its Low CirculatingPre-Operative Concentrations Predict Worse Type 2 Diabetes Remission afterBariatric Surgery in Obese Patients. J Clin Med. 2019 Apr 9;8(4). pii: E479. doi:10.3390/jcm8040479. PubMed PMID: 30970605; PubMed Central PMCID: PMC6518381. See more on PubMed
  • Karapanagiotou EM, Tsochatzis EA, Dilana KD, Tourkantonis I, Gratsias I,Syrigos KN. The significance of leptin, adiponectin, and resistin serum levels innon-small cell lung cancer (NSCLC). Lung Cancer. 2008 Sep;61(3):391-7. doi:10.1016/j.lungcan.2008.01.018. Epub 2008 Mar 14. PubMed PMID: 18342391. See more on PubMed
  • Kim SJ, Yoon SH, Choi SM, Lee J, Lee CH, Han SK, Yim JJ. Characteristicsassociated with progression in patients with of nontuberculous mycobacterial lungdisease : a prospective cohort study. BMC Pulm Med. 2017 Jan 5;17(1):5. doi:10.1186/s12890-016-0349-3. PubMed PMID: 28056937; PubMed Central PMCID:PMC5216528. See more on PubMed
  • Kojima R, Ukawa S, Zhao W, Suzuki K, Yamada H, Tsushita K, Kawamura T,Okabayashi S, Wakai K, Noma H, Ando M, Tamakoshi A. Association of AdiponectinWith Cancer and All-Cause Mortality in a Japanese Community-Dwelling ElderlyCohort: A Case-Cohort Study. J Epidemiol. 2018 Aug 5;28(8):367-372. doi:10.2188/jea.JE20170087. Epub 2018 Mar 24. PubMed PMID: 29576602; PubMed CentralPMCID: PMC6048298. See more on PubMed
  • Lamounier-Zepter V, Bornstein SR, Kunes J, Zicha J, Krsek M, Ehrhart-BornsteinM, Ziegler CG, Kiessling A, Funk RH, Haluzik M. Adrenocortical changes andarterial hypertension in lipoatrophic A-ZIP/F-1 mice. Mol Cell Endocrinol. 2008Jan 2;280(1-2):39-46. Epub 2007 Oct 18. PubMed PMID: 18045774. See more on PubMed
  • Larsson MW, Lind MV, Larnkjær A, Due AP, Blom IC, Wells J, Lai CT, Mølgaard C,Geddes DT, Michaelsen KF. Excessive Weight Gain Followed by Catch-Down inExclusively Breastfed Infants: An Exploratory Study. Nutrients. 2018 Sep12;10(9). pii: E1290. doi: 10.3390/nu10091290. PubMed PMID: 30213080; PubMedCentral PMCID: PMC6164044. See more on PubMed
  • Leclerc L, Thorin C, Flanagan J, Biourge V, Serisier S, Nguyen P. Higherneonatal growth rate and body condition score at 7 months are predictive factors of obesity in adult female Beagle dogs. BMC Vet Res. 2017 Apr 13;13(1):104. doi: 10.1186/s12917-017-0994-7. PubMed PMID: 28407742; PubMed Central PMCID:PMC5390368. See more on PubMed
  • Luque-Ramírez M, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E,Insenser M, Alpañés M, Escobar-Morreale HF. Sexual dimorphism in adipose tissuefunction as evidenced by circulating adipokine concentrations in the fastingstate and after an oral glucose challenge. Hum Reprod. 2013 Jul;28(7):1908-18.doi: 10.1093/humrep/det097. Epub 2013 Apr 4. PubMed PMID: 23559188. See more on PubMed
  • Marinoni E, Letizia C, Ciardo F, Corona G, Moscarini M, Di Iorio R. Effects ofprenatal betamethasone administration on leptin and adiponectin concentrations inmaternal and fetal circulation. Am J Obstet Gynecol. 2008 Aug;199(2):141.e1-6.doi: 10.1016/j.ajog.2008.02.047. Epub 2008 May 23. PubMed PMID: 18456235. See more on PubMed
  • Mazloomi S, Alizadeh N, Aminzare M, Niroomand S, Mousavi SN. RETRACTEDARTICLE: Serum Zinc and Adiponectin Levels in Patients with Polycystic OvarySyndrome, Adjusted for Anthropometric, Biochemical, Dietary Intake, and Physical Activity Measures. Biol Trace Elem Res. 2018 Feb;181(2):388. doi:10.1007/s12011-017-0951-0. Epub 2017 Feb 3. Retraction in:10.1007/s12011-017-0951-0. PubMed PMID: 28160242. See more on PubMed
  • Mierzyński R, Dłuski D, Nowakowski Ł, Poniedziałek-Czajkowska E,Leszczyńska-Gorzelak B. Adiponectin and Omentin Levels as Predictive Biomarkersof Preterm Birth in Patients with Gestational Diabetes Mellitus. Biomed Res Int. 2018 Sep 18;2018:7154216. doi: 10.1155/2018/7154216. eCollection 2018. PubMedPMID: 30320137; PubMed Central PMCID: PMC6167585. See more on PubMed
  • Murdolo G, Hammarstedt A, Schmelz M, Jansson PA, Smith U. Acutehyperinsulinemia differentially regulates interstitial and circulatingadiponectin oligomeric pattern in lean and insulin-resistant, obese individuals. J Clin Endocrinol Metab. 2009 Nov;94(11):4508-16. doi: 10.1210/jc.2009-0431. Epub2009 Oct 9. PubMed PMID: 19820029. See more on PubMed
  • Onat A, Can G, Hergenç G, Küçükdurmaz Z, Uğur M, Yüksel H. High absolutecoronary disease risk among Turks: involvement of risk factors additional toconventional ones. Cardiology. 2010;115(4):297-306. doi: 10.1159/000312009. Epub 2010 Apr 16. PubMed PMID: 20395681. See more on PubMed
  • Onat A, Hergenç G, Agirbaşli M, Kaya Z, Can G, Unaltuna NE. Preheparin serumlipoprotein lipase mass interacts with gender, gene polymorphism and, positively,with smoking. Clin Chem Lab Med. 2009;47(2):208-15. doi: 10.1515/CCLM.2009.018.PubMed PMID: 19191728. See more on PubMed
  • Onat A, Hergenç G, Can G, Küçükdurmaz Z. Serum adiponectin confers littleprotection against diabetes and hypertension in Turkish men. Obesity (SilverSpring). 2009 Mar;17(3):564-70. doi: 10.1038/oby.2008.564. Epub 2008 Dec 18.PubMed PMID: 19238142. See more on PubMed
  • Onat A, Hergenç G, Dursunoğlu D, Küçükdurmaz Z, Bulur S, Can G. Relativelyhigh levels of serum adiponectin in obese women, a potential indicator ofanti-inflammatory dysfunction: relation to sex hormone-binding globulin. Int JBiol Sci. 2008 Jul 25;4(4):208-14. PubMed PMID: 18695734; PubMed Central PMCID:PMC2491727. See more on PubMed
  • Oranskiy SP, Yeliseyeva LN, Tsanaeva AV, Zaytseva NV. Body composition andserum levels of adiponectin, vascular endothelial growth factor, andinterleukin-6 in patients with rheumatoid arthritis. Croat Med J. 2012Aug;53(4):350-6. PubMed PMID: 22911528; PubMed Central PMCID: PMC3429942. See more on PubMed
  • Ortega-Senovilla H, Schaefer-Graf U, Meitzner K, Abou-Dakn M, Graf K,Kintscher U, Herrera E. Gestational diabetes mellitus causes changes in theconcentrations of adipocyte fatty acid-binding protein and other adipocytokinesin cord blood. Diabetes Care. 2011 Sep;34(9):2061-6. doi: 10.2337/dc11-0715. Epub2011 Jul 20. PubMed PMID: 21775757; PubMed Central PMCID: PMC3161255. See more on PubMed
  • Ott R, Stupin JH, Melchior K, Schellong K, Ziska T, Dudenhausen JW, Henrich W,Rancourt RC, Plagemann A. Alterations of adiponectin gene expression and DNAmethylation in adipose tissues and blood cells are associated with gestationaldiabetes and neonatal outcome. Clin Epigenetics. 2018 Oct 24;10(1):131. doi:10.1186/s13148-018-0567-z. PubMed PMID: 30355290; PubMed Central PMCID:PMC6201547. See more on PubMed
  • Otto C, Otto B, Frost RJ, Vogeser M, Pfeiffer AF, Spranger J, Parhofer KG.Short-term therapy with atorvastatin or fenofibrate does not affect plasmaghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixedhyperlipoproteinaemia. Acta Diabetol. 2007 Jun;44(2):65-8. Epub 2007 May 27.PubMed PMID: 17530469. See more on PubMed
  • Park E, Shin MJ, Chung N. The associations between serum leptin, adiponectinand intercellular adhesion molecule-1 in hypercholesterolemic patients. Nutr Res Pract. 2007 Spring;1(1):65-9. doi: 10.4162/nrp.2007.1.1.65. Epub 2007 Mar 31.PubMed PMID: 20535388; PubMed Central PMCID: PMC2882580. See more on PubMed
  • Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, OppertJM, Langin D, Martinez JA, Sørensen TI, Stich V. Total adiponectin andadiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study. Eur J Endocrinol. 2008 Apr;158(4):533-41. doi: 10.1530/EJE-07-0512. PubMed PMID: 18362301. See more on PubMed
  • Risch L, Hoefle G, Saely C, Berchthold S, Weber M, Gouya G, Rein P, Langer P, Marte T, Aczel S, Drexel H. Evaluation of two fully automated novel enzyme-linkedimmunosorbent assays for the determination of human adiponectin in serum. ClinChim Acta. 2006 Nov;373(1-2):121-6. Epub 2006 May 17. PubMed PMID: 16797517. See more on PubMed
  • Risch L, Saely C, Hoefle G, Rein P, Langer P, Gouya G, Marte T, Aczel S,Drexel H. Relationship between glomerular filtration rate and the adipokinesadiponectin, resistin and leptin in coronary patients with predominantly normalor mildly impaired renal function. Clin Chim Acta. 2007 Feb;376(1-2):108-13. Epub2006 Jul 29. PubMed PMID: 16956602. See more on PubMed
  • Saeidi A, Jabbour G, Ahmadian M, Abbassi-Daloii A, Malekian F, Hackney AC,Saedmocheshi S, Basati G, Ben Abderrahman A, Zouhal H. Independent and CombinedEffects of Antioxidant Supplementation and Circuit Resistance Training onSelected Adipokines in Postmenopausal Women. Front Physiol. 2019 Apr 26;10:484.doi: 10.3389/fphys.2019.00484. eCollection 2019. PubMed PMID: 31105587; PubMedCentral PMCID: PMC6499001. See more on PubMed
  • Sahebkar A, Watts GF. Fibrate therapy and circulating adiponectinconcentrations: a systematic review and meta-analysis of randomizedplacebo-controlled trials. Atherosclerosis. 2013 Sep;230(1):110-20. doi:10.1016/j.atherosclerosis.2013.06.026. Epub 2013 Jul 12. Review. PubMed PMID:23958262. See more on PubMed
  • Sáinz N, Rodríguez A, Catalán V, Becerril S, Ramírez B, Gómez-Ambrosi J,Frühbeck G. Leptin administration favors muscle mass accretion by decreasingFoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One. 2009 Sep 4;4(9):e6808. doi: 10.1371/journal.pone.0006808. PubMed PMID: 19730740; PubMed Central PMCID:PMC2733298. See more on PubMed
  • Santaniemi M, Kesäniemi YA, Ukkola O. Low plasma adiponectin concentration is an indicator of the metabolic syndrome. Eur J Endocrinol. 2006 Nov;155(5):745-50.PubMed PMID: 17062891. See more on PubMed
  • Selva DM, Lecube A, Hernández C, Baena JA, Fort JM, Simó R. Lowerzinc-alpha2-glycoprotein production by adipose tissue and liver in obese patientsunrelated to insulin resistance. J Clin Endocrinol Metab. 2009Nov;94(11):4499-507. doi: 10.1210/jc.2009-0758. Epub 2009 Jul 21. PubMed PMID:19622624. See more on PubMed
  • Serelis J, Kontogianni MD, Katsiougiannis S, Bletsa M, Tektonidou MG, SkopouliFN. Effect of anti-TNF treatment on body composition and serum adiponectin levelsof women with rheumatoid arthritis. Clin Rheumatol. 2008 Jun;27(6):795-7. doi:10.1007/s10067-008-0855-7. Epub 2008 Feb 28. PubMed PMID: 18305977. See more on PubMed
  • Schnabel R, Messow CM, Lubos E, Espinola-Klein C, Rupprecht HJ, Bickel C,Sinning C, Tzikas S, Keller T, Genth-Zotz S, Lackner KJ, Münzel TF, BlankenbergS. Association of adiponectin with adverse outcome in coronary artery diseasepatients: results from the AtheroGene study. Eur Heart J. 2008 Mar;29(5):649-57. doi: 10.1093/eurheartj/ehn009. Epub 2008 Feb 9. PubMed PMID: 18263867. See more on PubMed
  • Schön M, Kovaničová Z, Košutzká Z, Nemec M, Tomková M, Jacková L, Máderová D, Slobodová L, Valkovič P, Ukropec J, Ukropcová B. Effects of running onadiponectin, insulin and cytokines in cerebrospinal fluid in healthy youngindividuals. Sci Rep. 2019 Feb 13;9(1):1959. doi: 10.1038/s41598-018-38201-2.PubMed PMID: 30760755; PubMed Central PMCID: PMC6374465. See more on PubMed
  • Sodi R, Hazell MJ, Durham BH, Rees C, Ranganath LR, Fraser WD. The circulatingconcentration and ratio of total and high molecular weight adiponectin inpost-menopausal women with and without osteoporosis and its association with bodymass index and biochemical markers of bone metabolism. Clin Biochem. 2009Sep;42(13-14):1375-80. doi: 10.1016/j.clinbiochem.2009.06.003. Epub 2009 Jun 10. PubMed PMID: 19523465. See more on PubMed
  • Stejskal D, Karpisek M, Hanulova Z, Svestak M. Chemerin is an independentmarker of the metabolic syndrome in a Caucasian population--a pilot study. BiomedPap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Dec;152(2):217-21. PubMedPMID: 19219210. See more on PubMed
  • Stejskal D, Proskova J, Solichova P. Adiponectin added into the plasma ofhealthy probands does not affect platelet aggregability. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):89-90. PubMed PMID: 16936907. See more on PubMed
  • Szewczyk-Golec K, Rajewski P, Gackowski M, Mila-Kierzenkowska C, Wesołowski R,Sutkowy P, Pawłowska M, Woźniak A. Melatonin Supplementation Lowers OxidativeStress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet.Oxid Med Cell Longev. 2017;2017:8494107. doi: 10.1155/2017/8494107. Epub 2017 Sep21. PubMed PMID: 29142618; PubMed Central PMCID: PMC5632922. See more on PubMed
  • Šenolt L, Kuklová M, Cerezo LA, Hulejová H, Filková M, Bošanská L, Pecha O,Pavelka K, Haluzík M, Vencovský J. Adipokine profile is modulated in subcutaneousadipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. AnnRheum Dis. 2011 Nov;70(11):2054-6. doi: 10.1136/ard.2011.152603. Epub 2011 May27. PubMed PMID: 21622768. See more on PubMed
  • Teijeira-Fernandez E, Eiras S, Salgado Somoza A, Gonzalez-Juanatey JR.Baseline epicardial adipose tissue adiponectin levels predict cardiovascularoutcomes: a long-term follow-up study. Cytokine. 2012 Dec;60(3):674-80. doi:10.1016/j.cyto.2012.08.012. Epub 2012 Sep 11. PubMed PMID: 22974530. See more on PubMed
  • Tsai JP, Liou HH, Liu HM, Lee CJ, Lee RP, Hsu BG. Fasting serum fattyacid-binding protein 4 level positively correlates with metabolic syndrome inhemodialysis patients. Arch Med Res. 2010 Oct;41(7):536-40. doi:10.1016/j.arcmed.2010.09.007. PubMed PMID: 21167393. See more on PubMed
  • Tsioufis C, Dimitriadis K, Selima M, Thomopoulos C, Mihas C, Skiadas I,Tousoulis D, Stefanadis C, Kallikazaros I. Low-grade inflammation andhypoadiponectinaemia have an additive detrimental effect on aortic stiffness inessential hypertensive patients. Eur Heart J. 2007 May;28(9):1162-9. Epub 2007Apr 19. PubMed PMID: 17446227. See more on PubMed
  • Tuttolomondo A, La Placa S, Di Raimondo D, Bellia C, Caruso A, Lo Sasso B,Guercio G, Diana G, Ciaccio M, Licata G, Pinto A. Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations withclinical variables and cardiovascular co-morbidity. Cardiovasc Diabetol. 2010 Sep13;9:50. doi: 10.1186/1475-2840-9-50. PubMed PMID: 20836881; PubMed CentralPMCID: PMC2946274. See more on PubMed
  • Tvarijonaviciute A, Cerón JJ, Tecles F. Serum adiponectin concentration indogs - absence of diurnal variation and lack of effect of feeding andmethylprednisolone administration. Acta Vet Hung. 2012 Dec;60(4):489-500. doi:10.1556/AVet.2012.043. PubMed PMID: 23160031. See more on PubMed
  • Tvarijonaviciute A, Eralp O, Kocaturk M, Yilmaz Z, Ceron JJ. Adiponectin andIGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia. VetImmunol Immunopathol. 2011 Mar 15;140(1-2):147-51. doi:10.1016/j.vetimm.2010.11.011. Epub 2010 Nov 18. PubMed PMID: 21145113. See more on PubMed
  • Tvarijonaviciute A, Martínez-Subiela S, Ceron JJ. Validation of 2 commerciallyavailable enzyme-linked immunosorbent assays for adiponectin determination incanine serum samples. Can J Vet Res. 2010 Oct;74(4):279-85. PubMed PMID:21197228; PubMed Central PMCID: PMC2949341. See more on PubMed
  • Tvarijonaviciute A, Tecles F, Ceron JJ. Relationship between serumbutyrylcholinesterase and obesity in dogs: a preliminary report. Vet J. 2010Nov;186(2):197-200. doi: 10.1016/j.tvjl.2009.07.030. Epub 2009 Sep 3. PubMedPMID: 19733105. See more on PubMed
  • Vaverkova H, Karasek D, Novotny D, Jackuliakova D, Halenka M, Lukes J,Frohlich J. Positive association of adiponectin with soluble vascular celladhesion molecule sVCAM-1 levels in patients with vascular disease ordyslipidemia. Atherosclerosis. 2008 Apr;197(2):725-31. Epub 2007 Aug 21. PubMedPMID: 17714716. See more on PubMed
  • von Eynatten M, Liu D, Hock C, Oikonomou D, Baumann M, Allolio B, KorosoglouG, Morcos M, Campean V, Amann K, Lutz J, Heemann U, Nawroth PP, Bierhaus A,Humpert PM. Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes. Diabetes. 2009 Sep;58(9):2093-9. doi: 10.2337/db09-0204. Epub2009 Jun 9. PubMed PMID: 19509019; PubMed Central PMCID: PMC2731516. See more on PubMed
  • Waluga M, Hartleb M, Boryczka G, Kukla M, Zwirska-Korczala K. Serum adipokinesin inflammatory bowel disease. World J Gastroenterol. 2014 Jun 14;20(22):6912-7. doi: 10.3748/wjg.v20.i22.6912. PubMed PMID: 24944482; PubMed Central PMCID:PMC4051931. See more on PubMed
  • Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute AnaerobicExercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines - AComparison Between Sexes. Front Physiol. 2018 Dec 10;9:1782. doi:10.3389/fphys.2018.01782. eCollection 2018. PubMed PMID: 30618797; PubMed CentralPMCID: PMC6295572. See more on PubMed
  • Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton C, Carr A.Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus:Associations with Glycaemic Control, Obesity, and Smoking. Nutrients. 2017 Sep9;9(9). pii: E997. doi: 10.3390/nu9090997. PubMed PMID: 28891932; PubMed Central PMCID: PMC5622757. See more on PubMed
  • Wilson R, Willis J, Gearry RB, Hughes A, Lawley B, Skidmore P, Frampton C,Fleming E, Anderson A, Jones L, Tannock GW, Carr AC. SunGold KiwifruitSupplementation of Individuals with Prediabetes Alters Gut Microbiota andImproves Vitamin C Status, Anthropometric and Clinical Markers. Nutrients. 2018Jul 12;10(7). pii: E895. doi: 10.3390/nu10070895. PubMed PMID: 30002355; PubMedCentral PMCID: PMC6073280. See more on PubMed
  • Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance,adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.World J Gastroenterol. 2014 Aug 14;20(30):10449-56. doi:10.3748/wjg.v20.i30.10449. PubMed PMID: 25132761; PubMed Central PMCID:PMC4130852. See more on PubMed
  • Zapata RC, Meachem MD, Cardoso NC, Mehain SO, McMillan CJ, Snead ER, ChelikaniPK. Differential circulating concentrations of adipokines, glucagon and adropinin a clinical population of lean, overweight and diabetic cats. BMC Vet Res. 2017Apr 4;13(1):85. doi: 10.1186/s12917-017-1011-x. PubMed PMID: 28376869; PubMedCentral PMCID: PMC5379571. See more on PubMed
Summary References (17)

References to Adiponectin

  • Lam KS, Xu A. Adiponectin: protection of the endothelium. Curr Diab Rep. 2005, 5, 254–259.
  • Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol. 2005, 166, 1655–1669.
  • Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Lam KS. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem. 2005, 280, 18073–18080.
  • Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 2005, 280, 18341–18347.
  • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004, 279, 1304–1309.
  • Ishikawa Y, Akasaka Y, Ishii T, Yoda-Murakami M, Choi-Miura NH, Tomita M, Ito K, Zhang L, Akishima Y, Ishihara M, Muramatsu M, Taniyama M. Changes in the distribution pattern of gelatinbinding protein of 28 kDa (adiponectin) in myocardial remodelling after ischaemic injury. Histopathology. 2003, 42, 43–52.
  • Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003, 148, 293–300.
  • Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003, 278, 40352–40363.
  • Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003, 423, 762–769.
  • Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem. 2003, 278, 2461–2468.
  • Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, Ohnuma H, Igarashi M, Tominaga M, Kato T. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care. 2003 Jul;26(7):2015–20.
  • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem. 2003, 278, 9073–9085.
  • Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. Adiponectin and protection against type 2 diabetes mellitus. Lancet. 2003, 361, 226–228.
  • Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, Ouchi N, Kihara S, Kawamoto T, Sumitsuji S, Funahashi T, Matsuzawa Y. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes. 2002, 51, 2325–2328.
  • Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002, 277, 19521–19529.
  • Tsao TS, Lodish HF, Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol. 2002, 440, 213–21.
  • Das K, Lin Y, Widen E, Zhang
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