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Manufactured by BioVendor

Club Cell Protein (CC16) Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:CC10, CC16, uteroglobin, urinary protein 1, Clara Cell Secretory Protein, Casein kinase 1, CK1
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price

RD191022200 96 wells (1 kit)
PubMed Product Details
Technical Data

Product has been modified

Clara Cell Protein Human ELISA has been renamed to Club Cell Protein (CC16) Human ELISA. This change respects a name-change policy of the major respiratory journals (including the journals of the American Thoracic Society, the European Respiratory Society and the American College of Chest Physicians) that went into effect beginning January 1, 2013.

Should you have any question, please contact the Technical Support Department.


Sandwich ELISA, Biotin-labelled antibody


Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

5 µl/well


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1.57–50 ng/ml

Limit of Detection

46 pg/ml

Intra-assay (Within-Run)

n = 8; CV = 3.4%

Inter-assay (Run-to-Run)

n = 4; CV = 4.7%

Spiking Recovery


Dilutation Linearity



  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • monkey Yes
  • mouse Yes
  • human Yes


  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 4 hours
  • The kit measures total Club cell protein in serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standard is recombinant protein (E. coli) based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Clinical use and areas of investigation:

  • Pneumonia and bronchopneumonia
  • Chronic obstructive pulmonary disease, sarcoidosis, pulmonary fibrosis
  • Acute lung injury
  • Asthma and allergic rhinitis
  • Lung cancer
  • IgA-nephropathy

Research topic

Immune Response, Infection and Inflammation, Pulmonary diseases


Human Club cell protein (CC16, CC10, uteroglobin, urinary protein 1 or Clara cell secretory
protein) is a member of the secretoglobin family of proteins and is a secreted product of nonciliated
bronchiolar Club cells. Its function remains to be fully elucidated but there is
convincing data suggesting its role as an immune-modulating and anti-inflammatory agent.
Club cell protein inhibits phospholipase A2 activity as well as interferon gamma signaling and
Th1 vs. Th2 lymphocyte regulation.

Club cell protein concentrations have been determined in serum, plasma and bronchoalveolar
lavage fluid in numerous studies since 1994. In serum, its increase is associated with age and
asbestos, nitrogen chloride and ozone exposure. Higher levels of CC16 were demonstrated in
patients with sarcoidosis, pulmonary fibrosis and high PEEP ventilation. Decreased serum
CC16 levels are found after pulmonary resection in smokers and in subjects with chronic
obstructive pulmonary disease, asthma or silica exposure.

Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from
pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic
fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears
to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac
pleural congestion.
Based on the above reports Club cell protein might be perspective useful diagnostic marker of
pulmonary diseases and injuries.

References to Product


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  • Benson M, Jansson L, Adner M, Luts A, Uddman R, Cardell LO. Gene profiling reveals decreased expression of uteroglobin and other anti-inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis. Clin Exp Allergy . Apr;35(4):473-8 (2005)
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  • Tufvesson E, Svensson H, Ankerst J, Bjermer L. Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled breath temperature and exhaled nitric oxide. Respir Med. 2013 Sep 6;
  • Ulvestad B, Randem BG, Andersson L, Ellingsen DG, Barregard L. Clara cell protein as a biomarker for lung epithelial injury in asphalt workers. J Occup Environ Med. 2007 Oct;49 (10):1073-8
  • Um SJ, Lam S, Coxson H, Man SF, Sin DD. Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients. PLoS One. 2013;8 (12):e83881
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  • Wutzler S, Lehnert T, Laurer H, Lehnert M, Becker M, Henrich D, Vogl T, Marzi I. Circulating levels of Clara cell protein 16 but not surfactant protein D identify and quantify lung damage in patients with multiple injuries. J Trauma. 2011 Aug;71 (2):E31-6
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  • Yang KD, Ou CY, Chang JC, Chen RF, Liu CA, Liang HM, Hsu TY, Chen LC, Huang SK. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol. 2007 Oct;120 (4):842-8
  • Biagioni BJ, Tam S, Chen YW, Sin DD, Carlsten C. Effect of controlled human exposure to diesel exhaust and allergen on airway surfactant protein D, myeloperoxidase and club (Clara) cell secretory protein 16. Clin Exp Allergy. 2016 Sep;46(9):1206-13. doi: 10.1111/cea.12732.
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References to Summary

References to Club Cell Protein

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  • Chowdhury B, Zhang Z, Mukherjee AB. Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin-IgA complex formation found in IgA-nephropathy. FEBS Lett. 82(5):611–5 (2008)
  • Braido F, Riccio AM, Guerra L, Gamalero C, Zolezzi A, Tarantini F, De Giovanni B, Folli C, Descalzi D, Canonica GW. Clara cell 16 protein in COPD sputum: a marker of small airways damage? Respir Med. 101(10):2119–24 (2007)
  • Shijubo N., Kawabata I., Sato N., Itoh Y.: Clinical Aspects of Clara Cell 10-kDa Protein/ Uteroglobin (Secretoglobin 1A1), Current Pharmaceutical Design, 9, 1139–1149, (2003)
  • Nord M., Schubert K., Cassel T., Andersson O., Riise G.: Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients. Transplantation, 73, 1264–1269, (2002)
  • Petrek M., Hermans C., Kolek V., Fialova J., Bernard A.: Clara cell protein (CC16) in serum and bronchoalveolar lavage fluid of subjects exposed to asbestos. Biomarkers, 7(1), 58–67, (2002)
  • Hermans C., Petrek M., Kolek V., Weynand B., Pieters T., Lambert M., Bernard A.: Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis. Eur Respir J, 18(3), 507–514 (2001)
  • Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A. et al.: Human urinary protein 1: Evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. Clin Chim Acta, 207, 239–249, (1992)
  • Bernard A., Lauwerys R., Noel A., Vandeleene B., Lambert A.: Urine protein 1: a sexdependent marker of tubular or glomerular dysfunction. Clin Chem, 35, 2141–2142, (1989)
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