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Club Cell Protein (CC16) Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:CC10, CC16, uteroglobin, urinary protein 1, Clara Cell Secretory Protein, Casein kinase 1, CK1
  • Species:Human
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Cat. No. Size Price


RD191022200 96 wells (1 kit)
PubMed Product Details
Technical Data

Product has been modified

Clara Cell Protein Human ELISA has been renamed to Club Cell Protein (CC16) Human ELISA. This change respects a name-change policy of the major respiratory journals (including the journals of the American Thoracic Society, the European Respiratory Society and the American College of Chest Physicians) that went into effect beginning January 1, 2013.

Should you have any question, please contact the Technical Support Department.

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

5 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1.57–50 ng/ml

Limit of Detection

46 pg/ml

Intra-assay (Within-Run)

n = 8; CV = 3.4%

Inter-assay (Run-to-Run)

n = 4; CV = 4.7%

Spiking Recovery

96,00%

Dilution Linearity

103,60%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • monkey Yes
  • mouse Yes
  • human Yes
Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 4 hours
  • The kit measures total Club cell protein in serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standard is recombinant protein (E. coli) based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Clinical use and areas of investigation:

  • Pneumonia and bronchopneumonia
  • Chronic obstructive pulmonary disease, sarcoidosis, pulmonary fibrosis
  • Acute lung injury
  • Asthma and allergic rhinitis
  • Lung cancer
  • IgA-nephropathy

Research topic

Immune Response, Infection and Inflammation, Pulmonary diseases

Summary

Human Club cell protein (CC16, CC10, uteroglobin, urinary protein 1 or Clara cell secretory
protein) is a member of the secretoglobin family of proteins and is a secreted product of nonciliated
bronchiolar Club cells. Its function remains to be fully elucidated but there is
convincing data suggesting its role as an immune-modulating and anti-inflammatory agent.
Club cell protein inhibits phospholipase A2 activity as well as interferon gamma signaling and
Th1 vs. Th2 lymphocyte regulation.

Club cell protein concentrations have been determined in serum, plasma and bronchoalveolar
lavage fluid in numerous studies since 1994. In serum, its increase is associated with age and
asbestos, nitrogen chloride and ozone exposure. Higher levels of CC16 were demonstrated in
patients with sarcoidosis, pulmonary fibrosis and high PEEP ventilation. Decreased serum
CC16 levels are found after pulmonary resection in smokers and in subjects with chronic
obstructive pulmonary disease, asthma or silica exposure.

Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from
pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic
fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears
to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac
pleural congestion.
Based on the above reports Club cell protein might be perspective useful diagnostic marker of
pulmonary diseases and injuries.

Product References (70)

References

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  • Buendía-Roldán I, Ruiz V, Sierra P, Montes E, Ramírez R, Vega A, Salgado A,Vargas MH, Mejía M, Pardo A, Selman M. Increased Expression of CC16 in Patientswith Idiopathic Pulmonary Fibrosis. PLoS One. 2016 Dec 15;11(12):e0168552. doi:10.1371/journal.pone.0168552. eCollection 2016. PubMed PMID: 27977812; PubMedCentral PMCID: PMC5158056. See more on PubMed
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Summary References (10)

References to Club Cell Protein

  • Deraz T, Kamel TB, El-Mogy MI, Moustafa EH. Serum and nasal lavage fluid Clara cell protein decreases in children with allergic rhinitis. Int J Pediatr Otorhinolaryngol, 76(9):1241–4 (2012)
  • Wuetzler S, Backhaus L, Henrich D, Geiger E: Clara cell protein16: A biomarker for detecting secondary respiratory complications in patients with multiple injuries. J Trauma Acute Care Surgery 73(4): 838–842 (2012)
  • Chowdhury B, Zhang Z, Mukherjee AB. Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin-IgA complex formation found in IgA-nephropathy. FEBS Lett. 82(5):611–5 (2008)
  • Braido F, Riccio AM, Guerra L, Gamalero C, Zolezzi A, Tarantini F, De Giovanni B, Folli C, Descalzi D, Canonica GW. Clara cell 16 protein in COPD sputum: a marker of small airways damage? Respir Med. 101(10):2119–24 (2007)
  • Shijubo N., Kawabata I., Sato N., Itoh Y.: Clinical Aspects of Clara Cell 10-kDa Protein/ Uteroglobin (Secretoglobin 1A1), Current Pharmaceutical Design, 9, 1139–1149, (2003)
  • Nord M., Schubert K., Cassel T., Andersson O., Riise G.: Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients. Transplantation, 73, 1264–1269, (2002)
  • Petrek M., Hermans C., Kolek V., Fialova J., Bernard A.: Clara cell protein (CC16) in serum and bronchoalveolar lavage fluid of subjects exposed to asbestos. Biomarkers, 7(1), 58–67, (2002)
  • Hermans C., Petrek M., Kolek V., Weynand B., Pieters T., Lambert M., Bernard A.: Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis. Eur Respir J, 18(3), 507–514 (2001)
  • Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A. et al.: Human urinary protein 1: Evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. Clin Chim Acta, 207, 239–249, (1992)
  • Bernard A., Lauwerys R., Noel A., Vandeleene B., Lambert A.: Urine protein 1: a sexdependent marker of tubular or glomerular dysfunction. Clin Chem, 35, 2141–2142, (1989)
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