United States set
language
Menu Shopping cart $0 Search
Manufactured by BioVendor

Club Cell Protein (CC16) Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:CC10, CC16, uteroglobin, urinary protein 1, Clara Cell Secretory Protein, Casein kinase 1, CK1
  • Species:Human
Cat. No. Size Price


RD191022200 96 wells (1 kit) $590
PubMed Product Details
Technical Data

Product has been modified

Clara Cell Protein Human ELISA has been renamed to Club Cell Protein (CC16) Human ELISA. This change respects a name-change policy of the major respiratory journals (including the journals of the American Thoracic Society, the European Respiratory Society and the American College of Chest Physicians) that went into effect beginning January 1, 2013.

Should you have any question, please contact the Technical Support Department.

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate, COVID-19

Sample Requirements

5 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

1.57–50 ng/ml

Limit of Detection

46 pg/ml

Intra-assay (Within-Run)

n = 8; CV = 3.4%

Inter-assay (Run-to-Run)

n = 4; CV = 4.7%

Spiking Recovery

96,00%

Dilution Linearity

103,60%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • monkey Yes
  • mouse Yes
  • human Yes

Note

The kits are CE-IVD certified and intended for professional use.

Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 4 hours
  • The kit measures total Club cell protein in serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Quality Controls are human serum based
  • Standard is recombinant protein (E. coli) based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Clinical use and areas of investigation:

  • Pneumonia and bronchopneumonia
  • Chronic obstructive pulmonary disease, sarcoidosis, pulmonary fibrosis
  • Acute lung injury
  • Asthma and allergic rhinitis
  • Lung cancer
  • IgA-nephropathy

Research topic

Immune Response, Infection and Inflammation, Pulmonary diseases, COVID-19

Summary

Human Club cell protein (CC16, CC10, uteroglobin, urinary protein 1 or Clara cell secretory
protein) is a member of the secretoglobin family of proteins and is a secreted product of nonciliated
bronchiolar Club cells. Its function remains to be fully elucidated but there is
convincing data suggesting its role as an immune-modulating and anti-inflammatory agent.
Club cell protein inhibits phospholipase A2 activity as well as interferon gamma signaling and
Th1 vs. Th2 lymphocyte regulation.

Club cell protein concentrations have been determined in serum, plasma and bronchoalveolar
lavage fluid in numerous studies since 1994. In serum, its increase is associated with age and
asbestos, nitrogen chloride and ozone exposure. Higher levels of CC16 were demonstrated in
patients with sarcoidosis, pulmonary fibrosis and high PEEP ventilation. Decreased serum
CC16 levels are found after pulmonary resection in smokers and in subjects with chronic
obstructive pulmonary disease, asthma or silica exposure.

Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from
pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic
fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears
to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac
pleural congestion.
Based on the above reports Club cell protein might be perspective useful diagnostic marker of
pulmonary diseases and injuries.

Product References (75)

References

  • Naha N, Muhamed JCJ, Pagdhune A, Sarkar B, Sarkar K. Club cell protein 16 as a biomarker for early detection of silicosis. Indian J Med Res. 2020 Apr;151(4):319-325. doi: 10.4103/ijmr.IJMR_1799_18. PubMed PMID: 32461395. PubMed CentralPMCID: PMC7371066. See more on PubMed
  • Qaisar R, Karim A, Muhammad T. Circulating Biomarkers of Handgrip Strength and Lung Function in Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2020 Feb 11;15:311-321. doi: 10.2147/COPD.S225765. eCollection 2020. PubMed PMID: 32103930. PubMed CentralPMCID: PMC7023869. See more on PubMed
  • Santos JMBD, Foster R, Jonckheere AC, Rossi M, Luna Junior LA, Katekaru CM, de Sá MC, Pagani LG, Almeida FM, Amaral JDB, Vieira RP, Bachi ALL, Bullens DMA, Vaisberg M. Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses. Int J Environ Res Public Health. 2019 Nov 12;16(22):4418. doi: 10.3390/ijerph16224418. PubMed PMID: 31726719. PubMed CentralPMCID: PMC6887780. See more on PubMed
  • Beamer PI, Furlong M, Lothrop N, Guerra S, Billheimer D, Stern DA, Zhai J, Halonen M, Wright AL, Martinez FD. CC16 Levels into Adult Life Are Associated with Nitrogen Dioxide Exposure at Birth. Am J Respir Crit Care Med. 2019 Sep 1;200(5):600-607. doi: 10.1164/rccm.201808-1488OC. PubMed PMID: 30789752. PubMed CentralPMCID: PMC6727155. See more on PubMed
  • Wu CY, Cheng YJ, Hung MH, Lin IJ, Sun WZ, Chan KC. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. Biomed Res Int. 2019 Apr 11;2019:8958069. doi: 10.1155/2019/8958069. eCollection 2019. PubMed PMID: 31111072. PubMed CentralPMCID: PMC6487165. See more on PubMed
  • Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, Wright AL, Halonen M, Martinez FD, Kraft M, Guerra S, Ledford JG. Club Cell Secretory Protein Deficiency Leads to Altered Lung Function. Am J Respir Crit Care Med. 2019 Feb 1;199(3):302-312. doi: 10.1164/rccm.201807-1345OC. PubMed PMID: 30543455. PubMed CentralPMCID: PMC6363971. See more on PubMed
  • Hagman C, Björklund LJ, Hellgren G, Tufvesson E, Hansen-Pupp I. Club cell secretory protein (CC16) in gastric fluid at birth and subsequent lung disease in preterm infants. Pediatr Pulmonol. 2018 Oct;53(10):1399-1406. doi: 10.1002/ppul.24128. Epub 2018 Jul 10. PubMed PMID: 29992757. See more on PubMed
  • Kirkhus NE, Ulvestad B, Barregard L, Skare Ø, Olsen R, Thomassen Y, Ellingsen DG. Pneumoproteins in Offshore Drill Floor Workers. Int J Environ Res Public Health. 2019 Jan 23;16(3):300. doi: 10.3390/ijerph16030300. PubMed PMID: 30678045. PubMed CentralPMCID: PMC6388385. See more on PubMed
  • Raulf M, van Kampen V, Neumann HD, Liebers V, Deckert A, Brüning T, Bünger J, Hoffmeyer F. Airway and Blood Inflammatory Markers in Waste Collectors. Adv Exp Med Biol. 2017;1021:1-14. doi: 10.1007/5584_2017_25. PubMed PMID: 28405893. See more on PubMed
  • Lam DC, Kwok HH, Yu WC, Ko FW, Tam CY, Lau AC, Fong DY, Ip MS. CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers. BMC Pulm Med. 2018 Mar 16;18(1):47. doi: 10.1186/s12890-018-0607-7. PubMed PMID: 29548305. PubMed CentralPMCID: PMC5857103. See more on PubMed
  • Oh JY, Lee YS, Min KH, Hur GY, Lee SY, Kang KH, Rhee CK, Park SJ, Shim JJ. Decreased serum club cell secretory protein in asthma and chronic obstructive pulmonary disease overlap: a pilot study. Int J Chron Obstruct Pulmon Dis. 2018 Oct 18;13:3411-3417. doi: 10.2147/COPD.S174545. eCollection 2018. PubMed PMID: 30425470. PubMed CentralPMCID: PMC6203108. See more on PubMed
  • Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF. Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. Thorax. 2018 Aug;73(8):723-730. doi: 10.1136/thoraxjnl-2017-210305. Epub 2018 Jan 29. PubMed PMID: 29382797. PubMed CentralPMCID: PMC6204954. See more on PubMed
  • Monsé C, Hagemeyer O, Raulf M, Jettkant B, van Kampen V, Kendzia B, Gering V, Kappert G, Weiss T, Ulrich N, Marek EM, Bünger J, Brüning T, Merget R. Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers. Part Fibre Toxicol. 2018 Feb 12;15(1):8. doi: 10.1186/s12989-018-0246-4. PubMed PMID: 29429408. PubMed CentralPMCID: PMC5808398. See more on PubMed
  • Wu CY, Lu YF, Wang ML, Chen JS, Hsu YC, Yang FS, Cheng YJ. Effects of Dexmedetomidine Infusion on Inflammatory Responses and Injury of Lung Tidal Volume Changes during One-Lung Ventilation in Thoracoscopic Surgery: A Randomized Controlled Trial. Mediators Inflamm. 2018 Apr 5;2018:2575910. doi: 10.1155/2018/2575910. eCollection 2018. PubMed PMID: 29853785. PubMed CentralPMCID: PMC5952437. See more on PubMed
  • Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS. Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries. Trauma Surg Acute Care Open. 2017 Aug 28;2(1):e000121. doi: 10.1136/tsaco-2017-000121. eCollection 2017. PubMed PMID: 29766112. PubMed CentralPMCID: PMC5887582. See more on PubMed
  • Ilic N, Mihailovic N. Serum Clara cell protein and atopic phenotype in children up to 2 years of age. J Clin Lab Anal. 2017 Nov;31(6):e22151. doi: 10.1002/jcla.22151. Epub 2017 Feb 1. PubMed PMID: 28146340. PubMed CentralPMCID: PMC6817215. See more on PubMed
  • Guzmán-Bárcenas J, Calderón-Moore A, Baptista-González H, Irles C. Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study. Can Respir J. 2017;2017:8074678. doi: 10.1155/2017/8074678. Epub 2017 Apr 11. PubMed PMID: 28487624. PubMed CentralPMCID: PMC5405359. See more on PubMed
  • Biagioni BJ, Tam S, Chen YW, Sin DD, Carlsten C. Effect of controlled human exposure to diesel exhaust and allergen on airway surfactant protein D, myeloperoxidase and club (Clara) cell secretory protein 16. Clin Exp Allergy. 2016 Sep;46(9):1206-13. doi: 10.1111/cea.12732. Epub 2016 May 12. PubMed PMID: 27018153. See more on PubMed
  • Chen Y, Vasquez MM, Zhu L, Lizarraga RE, Krutzsch M, Einspahr J, Alberts DS, Di PYP, Martinez FD, Guerra S. Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med. 2017 Oct 1;196(7):928-931. doi: 10.1164/rccm.201608-1611LE. PubMed PMID: 28231434. PubMed CentralPMCID: PMC5649971. See more on PubMed
  • Dierschke K, Isaxon C, Andersson UBK, Assarsson E, Axmon A, Stockfelt L, Gudmundsson A, Jönsson BAG, Kåredal M, Löndahl J, Pagels J, Wierzbicka A, Bohgard M, Nielsen J. Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates. Int Arch Occup Environ Health. 2017 Jul;90(5):451-463. doi: 10.1007/s00420-017-1209-z. Epub 2017 Mar 3. PubMed PMID: 28258373. PubMed CentralPMCID: PMC5486570. See more on PubMed
  • Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016 Dec;9(12):906-914. doi: 10.1158/1940-6207.CAPR-15-0254. Epub 2016 Sep 22. PubMed PMID: 27658890. PubMed CentralPMCID: PMC5136333. See more on PubMed
  • Vasquez MM, Hu C, Roe DJ, Chen Z, Halonen M, Guerra S. Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application. BMC Med Res Methodol. 2016 Nov 14;16(1):154. doi: 10.1186/s12874-016-0254-8. PubMed PMID: 27842498. PubMed CentralPMCID: PMC5109787. See more on PubMed
  • Romberg K, Tufvesson E, Bjermer L. Asthma symptoms, mannitol reactivity and exercise-induced bronchoconstriction in adolescent swimmers versus tennis players. J Asthma Allergy. 2017 Oct 3;10:249-260. doi: 10.2147/JAA.S134794. eCollection 2017. PubMed PMID: 29042799. PubMed CentralPMCID: PMC5633302. See more on PubMed
  • Buendía-Roldán I, Ruiz V, Sierra P, Montes E, Ramírez R, Vega A, Salgado A, Vargas MH, Mejía M, Pardo A, Selman M. Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016 Dec 15;11(12):e0168552. doi: 10.1371/journal.pone.0168552. eCollection 2016. PubMed PMID: 27977812. PubMed CentralPMCID: PMC5158056. See more on PubMed
  • Knabe L, Varilh J, Bergougnoux A, Gamez AS, Bonini J, Pommier A, Petit A, Molinari N, Vachier I, Taulan-Cadars M, Bourdin A. CCSP G38A polymorphism environment interactions regulate CCSP levels differentially in COPD. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L696-L703. doi: 10.1152/ajplung.00280.2016. Epub 2016 Aug 5. PubMed PMID: 27496897. See more on PubMed
  • Holz O, Tan L, Schaumann F, Müller M, Scholl D, Hidi R, McLeod A, Krug N, Hohlfeld JM. Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers. Pulm Pharmacol Ther. 2015 Dec;35:50-9. doi: 10.1016/j.pupt.2015.10.011. Epub 2015 Nov 10. PubMed PMID: 26545873. See more on PubMed
  • Kokuho N, Ishii T, Kamio K, Hayashi H, Kurahara M, Hattori K, Motegi T, Azuma A, Gemma A, Kida K. Diagnostic Values For Club Cell Secretory Protein (CC16) in Serum of Patients of Combined Pulmonary Fibrosis and Emphysema. COPD. 2015 Aug;12(4):347-54. doi: 10.3109/15412555.2014.948994. PubMed PMID: 25244495. See more on PubMed
  • Guerra S, Halonen M, Vasquez MM, Spangenberg A, Stern DA, Morgan WJ, Wright AL, Lavi I, Tarès L, Carsin AE, Dobaño C, Barreiro E, Zock JP, Martínez-Moratalla J, Urrutia I, Sunyer J, Keidel D, Imboden M, Probst-Hensch N, Hallberg J, Melén E, Wickman M, Bousquet J, Belgrave DC, Simpson A, Custovic A, Antó JM, Martinez FD. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med. 2015 Aug;3(8):613-20. doi: 10.1016/S2213-2600(15)00196-4. Epub 2015 Jul 6. PubMed PMID: 26159408. PubMed CentralPMCID: PMC4640928. See more on PubMed
  • Karottki DG, Spilak M, Frederiksen M, Jovanovic Andersen Z, Madsen AM, Ketzel M, Massling A, Gunnarsen L, Møller P, Loft S. Indoor and outdoor exposure to ultrafine, fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of elderly urban citizens. Int J Environ Res Public Health. 2015 Feb 2;12(2):1667-86. doi: 10.3390/ijerph120201667. PubMed PMID: 25648225. PubMed CentralPMCID: PMC4344687. See more on PubMed
  • Burki NK, Tetenta SU. Inflammatory response to acute hypoxia in humans. Pulm Pharmacol Ther. 2014 Apr;27(2):208-11. doi: 10.1016/j.pupt.2013.05.008. Epub 2013 May 29. PubMed PMID: 23727146. See more on PubMed
  • Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep;121(3):469-81. doi: 10.1097/ALN.0000000000000301. PubMed PMID: 24809976. PubMed CentralPMCID: PMC4165799. See more on PubMed
  • Bønløkke JH, Riddervold IS, Grønborg TK, Skogstrand K, Hougaard DM, Barregard L, Sigsgaard T. Systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers. J Occup Environ Med. 2014 Feb;56(2):177-83. doi: 10.1097/JOM.0000000000000067. PubMed PMID: 24451613. PubMed CentralPMCID: PMC3921260. See more on PubMed
  • Kippelen P, Tufvesson E, Ali L, Bjermer L, Anderson SD. Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes. Respir Med. 2013 Dec;107(12):1837-44. doi: 10.1016/j.rmed.2013.09.020. Epub 2013 Oct 2. PubMed PMID: 24120076. See more on PubMed
  • Um SJ, Lam S, Coxson H, Man SF, Sin DD. Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients. PLoS One. 2013 Dec 26;8(12):e83881. doi: 10.1371/journal.pone.0083881. eCollection 2013. PubMed PMID: 24386300. PubMed CentralPMCID: PMC3873417. See more on PubMed
  • Tufvesson E, Svensson H, Ankerst J, Bjermer L. Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled breath temperature and exhaled nitric oxide. Respir Med. 2013 Nov;107(11):1675-81. doi: 10.1016/j.rmed.2013.08.004. Epub 2013 Sep 6. PubMed PMID: 24018107. See more on PubMed
  • Ho JC, Au WY, Han L, Kwong YL, Ip MS. Effect of therapeutic arsenic exposure on pulmonary function. Respir Med. 2013 Sep;107(9):1423-30. doi: 10.1016/j.rmed.2013.06.012. Epub 2013 Jul 5. PubMed PMID: 23835189. See more on PubMed
  • Fernández-Luna Á, Gallardo L, Plaza-Carmona M, García-Unanue J, Sánchez-Sánchez J, Felipe JL, Burillo P, Ara I. Respiratory function and changes in lung epithelium biomarkers after a short-training intervention in chlorinated vs. ozone indoor pools. PLoS One. 2013 Jul 12;8(7):e68447. doi: 10.1371/journal.pone.0068447. Print 2013. PubMed PMID: 23874631. PubMed CentralPMCID: PMC3709909. See more on PubMed
  • Mickleborough TD, Vaughn CL, Shei RJ, Davis EM, Wilhite DP. Marine lipid fraction PCSO-524 (lyprinol/omega XL) of the New Zealand green lipped mussel attenuates hyperpnea-induced bronchoconstriction in asthma. Respir Med. 2013 Aug;107(8):1152-63. doi: 10.1016/j.rmed.2013.04.010. Epub 2013 May 7. PubMed PMID: 23660397. See more on PubMed
  • Vizcaya D, Mirabelli MC, Orriols R, Antó JM, Barreiro E, Burgos F, Arjona L, Gomez F, Zock JP. Functional and biological characteristics of asthma in cleaning workers. Respir Med. 2013 May;107(5):673-83. doi: 10.1016/j.rmed.2013.01.011. Epub 2013 Feb 20. PubMed PMID: 23433770. See more on PubMed
  • Rava M, Tares L, Lavi I, Barreiro E, Zock JP, Ferrer A, Muniozguren N, Nadif R, Cazzoletti L, Kauffmann F, Anto JM, Guerra S. Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population. J Allergy Clin Immunol. 2013 Jul;132(1):230-2. doi: 10.1016/j.jaci.2013.01.023. Epub 2013 Mar 6. PubMed PMID: 23473837. See more on PubMed
  • Heldal KK, Barregard L, Larsson P, Ellingsen DG. Pneumoproteins in sewage workers exposed to sewage dust. Int Arch Occup Environ Health. 2013 Jan;86(1):65-70. doi: 10.1007/s00420-012-0747-7. Epub 2012 Feb 17. PubMed PMID: 22350277. PubMed CentralPMCID: PMC3535374. See more on PubMed
  • Duda I, Grzybowska K, Jędrzejowska-Szypułka H, Lewin-Kowalik J. The sitting position during neurosurgical procedures does not influence serum biomarkers of pulmonary parenchymal injury. BMC Surg. 2012 Dec 5;12:24. doi: 10.1186/1471-2482-12-24. PubMed PMID: 23217172. PubMed CentralPMCID: PMC3521202. See more on PubMed
  • Aul R, Armstrong J, Duvoix A, Lomas D, Hayes B, Miller BE, Jagger C, Singh D. Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects. Br J Clin Pharmacol. 2012 Dec;74(6):1023-32. doi: 10.1111/j.1365-2125.2012.04287.x. PubMed PMID: 22469312. PubMed CentralPMCID: PMC3522816. See more on PubMed
  • Engström G, Lindberg C, Gerhardsson de Verdier M, Nihlén U, Anderson M, Svartengren M, Forsman-Semb K. Blood biomarkers and measures of pulmonary function--a study from the Swedish twin registry. Respir Med. 2012 Sep;106(9):1250-7. doi: 10.1016/j.rmed.2012.05.004. Epub 2012 Jun 9. PubMed PMID: 22687639. See more on PubMed
  • Hüttmann EM, Greulich T, Hattesohl A, Schmid S, Noeske S, Herr C, John G, Jörres RA, Müller B, Vogelmeier C, Koczulla AR. Comparison of two devices and two breathing patterns for exhaled breath condensate sampling. PLoS One. 2011;6(11):e27467. doi: 10.1371/journal.pone.0027467. Epub 2011 Nov 7. PubMed PMID: 22087323. PubMed CentralPMCID: PMC3210176. See more on PubMed
  • Dickens JA, Miller BE, Edwards LD, Silverman EK, Lomas DA, Tal-Singer R. COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir Res. 2011 Nov 4;12(1):146. doi: 10.1186/1465-9921-12-146. PubMed PMID: 22054035. PubMed CentralPMCID: PMC3247194. See more on PubMed
  • Wutzler S, Lehnert T, Laurer H, Lehnert M, Becker M, Henrich D, Vogl T, Marzi I. Circulating levels of Clara cell protein 16 but not surfactant protein D identify and quantify lung damage in patients with multiple injuries. J Trauma. 2011 Aug;71(2):E31-6. doi: 10.1097/TA.0b013e3181f6f0b4. PubMed PMID: 21045740. See more on PubMed
  • Diamond JM, Kawut SM, Lederer DJ, Ahya VN, Kohl B, Sonett J, Palmer SM, Crespo M, Wille K, Lama VN, Shah PD, Orens J, Bhorade S, Weinacker A, Demissie E, Bellamy S, Christie JD, Ware LB. Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction. Am J Transplant. 2011 Mar;11(3):561-7. doi: 10.1111/j.1600-6143.2010.03431.x. Epub 2011 Feb 7. PubMed PMID: 21299834. PubMed CentralPMCID: PMC3079443. See more on PubMed
  • Romberg K, Bjermer L, Tufvesson E. Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. Respir Med. 2011 Jan;105(1):31-6. doi: 10.1016/j.rmed.2010.07.012. Epub 2010 Aug 8. PubMed PMID: 20696561. See more on PubMed
  • Vaes B, Pasquet A, Wallemacq P, Rezzoug N, Mekouar H, Olivier PA, Legrand D, Matheï C, Van Pottelbergh G, Degryse J. The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium. BMC Geriatr. 2010 Jun 17;10:39. doi: 10.1186/1471-2318-10-39. PubMed PMID: 20565795. PubMed CentralPMCID: PMC2906485. See more on PubMed
  • Ellingsen DG, Ulvestad B, Andersson L, Barregard L. Pneumoproteins and inflammatory biomarkers in asphalt pavers. Biomarkers. 2010 Sep;15(6):498-507. doi: 10.3109/1354750X.2010.490305. PubMed PMID: 20528258. See more on PubMed
  • Bourdin A, Kotsimbos T, Nguyen K, Vachier I, Mainprice B, Farce M, Paganin F, Marty-Ané C, Vernhet H, Godard P, Chanez P. Non-invasive assessment of small airway remodelling in smokers. COPD. 2010 Apr;7(2):102-10. doi: 10.3109/15412551003631709. PubMed PMID: 20397810. See more on PubMed
  • Kucejko W, Chyczewska E, Naumnik W, Ossolińska M. Concentration of surfactant protein D, Clara cell protein CC-16 and IL-10 in bronchoalveolar lavage (BAL) in patients with sarcoidosis, hypersensivity pneumonitis and idiopathic pulmonary fibrosis. Folia Histochem Cytobiol. 2009;47(2):225-30. doi: 10.2478/v10042-009-0028-9. PubMed PMID: 19995708. See more on PubMed
  • Chimenti L, Morici G, Paterno A, Bonanno A, Vultaggio M, Bellia V, Bonsignore MR. Environmental conditions, air pollutants, and airway cells in runners: a longitudinal field study. J Sports Sci. 2009 Jul;27(9):925-35. doi: 10.1080/02640410902946493. PubMed PMID: 19629842. See more on PubMed
  • Kropski JA, Fremont RD, Calfee CS, Ware LB. Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury. Chest. 2009 Jun;135(6):1440-1447. doi: 10.1378/chest.08-2465. Epub 2009 Feb 2. PubMed PMID: 19188556. PubMed CentralPMCID: PMC2716712. See more on PubMed
  • Sarafidis K, Stathopoulou T, Diamanti E, Soubasi V, Agakidis C, Balaska A, Drossou V. Clara cell secretory protein (CC16) as a peripheral blood biomarker of lung injury in ventilated preterm neonates. Eur J Pediatr. 2008 Nov;167(11):1297-303. doi: 10.1007/s00431-008-0712-3. Epub 2008 Jun 3. PubMed PMID: 18521628. See more on PubMed
  • Liu Z, Lu X, Zhang XH, Bochner BS, Long XB, Zhang F, Wang H, Cui YH. Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa. Allergy. 2009 Jan;64(1):149-57. doi: 10.1111/j.1398-9995.2008.01847.x. Epub 2008 Dec 12. PubMed PMID: 19076932. See more on PubMed
  • Gaber F, Daham K, Higashi A, Higashi N, Gülich A, Delin I, James A, Skedinger M, Gyllfors P, Nord M, Dahlén SE, Kumlin M, Dahlén B. Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from patients with aspirin-intolerant asthma. Thorax. 2008 Dec;63(12):1076-82. doi: 10.1136/thx.2008.101196. Epub 2008 Aug 29. PubMed PMID: 18757457. See more on PubMed
  • Lomas DA, Silverman EK, Edwards LD, Miller BE, Coxson HO, Tal-Singer R. Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort. Thorax. 2008 Dec;63(12):1058-63. doi: 10.1136/thx.2008.102574. Epub 2008 Aug 29. PubMed PMID: 18757456. See more on PubMed
  • Alexis NE, Lay JC, Haczku A, Gong H, Linn W, Hazucha MJ, Harris B, Tal-Singer R, Peden DB. Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers. Environ Health Perspect. 2008 Jun;116(6):799-805. doi: 10.1289/ehp.10981. PubMed PMID: 18560537. PubMed CentralPMCID: PMC2430237. See more on PubMed
  • Madsen C, Durand KL, Nafstad P, Schwarze PE, Rønningen KS, Håheim LL. Associations between environmental exposures and serum concentrations of Clara cell protein among elderly men in Oslo, Norway. Environ Res. 2008 Nov;108(3):354-60. doi: 10.1016/j.envres.2008.07.017. Epub 2008 Aug 30. PubMed PMID: 18762291. See more on PubMed
  • Sims MW, Tal-Singer RM, Kierstein S, Musani AI, Beers MF, Panettieri RA, Haczku A. Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir Res. 2008 Jan 28;9(1):13. doi: 10.1186/1465-9921-9-13. PubMed PMID: 18226251. PubMed CentralPMCID: PMC2249580. See more on PubMed
  • Wang SX, Liu P, Wei MT, Chen L, Guo Y, Wang RY, Tu ZG, Liang XC. Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis. J Occup Environ Med. 2007 Aug;49(8):834-9. doi: 10.1097/JOM.0b013e318124a927. PubMed PMID: 17693780. See more on PubMed
  • Ulvestad B, Randem BG, Andersson L, Ellingsen DG, Barregard L. Clara cell protein as a biomarker for lung epithelial injury in asphalt workers. J Occup Environ Med. 2007 Oct;49(10):1073-8. doi: 10.1097/JOM.0b013e3181570726. PubMed PMID: 18000412. See more on PubMed
  • Sin DD, Leung R, Gan WQ, Man SP. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm Med. 2007 Oct 8;7:13. doi: 10.1186/1471-2466-7-13. PubMed PMID: 17922919. PubMed CentralPMCID: PMC2096624. See more on PubMed
  • Yang KD, Ou CY, Chang JC, Chen RF, Liu CA, Liang HM, Hsu TY, Chen LC, Huang SK. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol. 2007 Oct;120(4):842-8. doi: 10.1016/j.jaci.2007.07.009. Epub 2007 Aug 22. PubMed PMID: 17716718. See more on PubMed
  • Coppens JT, Van Winkle LS, Pinkerton K, Plopper CG. Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys. Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1155-62. doi: 10.1152/ajplung.00454.2006. Epub 2007 Jan 19. PubMed PMID: 17237148. See more on PubMed
  • Harvey BG, Heguy A, Leopold PL, Carolan BJ, Ferris B, Crystal RG. Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med (Berl). 2007 Jan;85(1):39-53. doi: 10.1007/s00109-006-0103-z. Epub 2006 Nov 8. PubMed PMID: 17115125. See more on PubMed
  • Benson M, Fransson M, Martinsson T, Naluai AT, Uddman R, Cardell LO. Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis. Allergy. 2007 Feb;62(2):178-83. doi: 10.1111/j.1398-9995.2006.01264.x. PubMed PMID: 17298427. See more on PubMed
  • Fransson M, Adner M, Uddman R, Cardell LO. Lipopolysaccharide-induced down-regulation of uteroglobin in the human nose. Acta Otolaryngol. 2007 Mar;127(3):285-91. doi: 10.1080/00016480600801340. PubMed PMID: 17364366. See more on PubMed
  • Andersson L, Lundberg PA, Barregard L. Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels. J Appl Toxicol. 2007 Jan-Feb;27(1):60-6. doi: 10.1002/jat.1184. PubMed PMID: 17186574. See more on PubMed
  • Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J, Martin T, Goodlett DR. Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol. 2006 Jul;169(1):86-95. doi: 10.2353/ajpath.2006.050612. PubMed PMID: 16816363. PubMed CentralPMCID: PMC1698774. See more on PubMed
  • Martin AC, Laing IA, Khoo SK, Zhang G, Rueter K, Teoh L, Taheri S, Hayden CM, Geelhoed GC, Goldblatt J, LeSouëf PN. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Am J Respir Crit Care Med. 2006 Mar 15;173(6):617-22. doi: 10.1164/rccm.200509-1367OC. Epub 2005 Dec 30. PubMed PMID: 16387800. See more on PubMed
  • Benson M, Jansson L, Adner M, Luts A, Uddman R, Cardell LO. Gene profiling reveals decreased expression of uteroglobin and other anti-inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis. Clin Exp Allergy. 2005 Apr;35(4):473-8. doi: 10.1111/j.1365-2222.2005.02206.x. PubMed PMID: 15836756. See more on PubMed
  • Mattsson J, Remberger M, Andersson O, Sundberg B, Nord M. Decreased serum levels of clara cell secretory protein (CC16) are associated with bronchiolitis obliterans and may permit early diagnosis in patients after allogeneic stem-cell transplantation. Transplantation. 2005 May 27;79(10):1411-6. doi: 10.1097/01.tp.0000158354.39635.ab. PubMed PMID: 15912112. See more on PubMed
Summary References (10)

References to Club Cell Protein

  • Deraz T, Kamel TB, El-Mogy MI, Moustafa EH. Serum and nasal lavage fluid Clara cell protein decreases in children with allergic rhinitis. Int J Pediatr Otorhinolaryngol, 76(9):1241–4 (2012)
  • Wuetzler S, Backhaus L, Henrich D, Geiger E: Clara cell protein16: A biomarker for detecting secondary respiratory complications in patients with multiple injuries. J Trauma Acute Care Surgery 73(4): 838–842 (2012)
  • Chowdhury B, Zhang Z, Mukherjee AB. Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin-IgA complex formation found in IgA-nephropathy. FEBS Lett. 82(5):611–5 (2008)
  • Braido F, Riccio AM, Guerra L, Gamalero C, Zolezzi A, Tarantini F, De Giovanni B, Folli C, Descalzi D, Canonica GW. Clara cell 16 protein in COPD sputum: a marker of small airways damage? Respir Med. 101(10):2119–24 (2007)
  • Shijubo N., Kawabata I., Sato N., Itoh Y.: Clinical Aspects of Clara Cell 10-kDa Protein/ Uteroglobin (Secretoglobin 1A1), Current Pharmaceutical Design, 9, 1139–1149, (2003)
  • Nord M., Schubert K., Cassel T., Andersson O., Riise G.: Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients. Transplantation, 73, 1264–1269, (2002)
  • Petrek M., Hermans C., Kolek V., Fialova J., Bernard A.: Clara cell protein (CC16) in serum and bronchoalveolar lavage fluid of subjects exposed to asbestos. Biomarkers, 7(1), 58–67, (2002)
  • Hermans C., Petrek M., Kolek V., Weynand B., Pieters T., Lambert M., Bernard A.: Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis. Eur Respir J, 18(3), 507–514 (2001)
  • Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A. et al.: Human urinary protein 1: Evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. Clin Chim Acta, 207, 239–249, (1992)
  • Bernard A., Lauwerys R., Noel A., Vandeleene B., Lambert A.: Urine protein 1: a sexdependent marker of tubular or glomerular dysfunction. Clin Chem, 35, 2141–2142, (1989)
Related Products Docs