Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Cystatin C Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Post G-globulin, Cystatin-3, Neuroendocrine basic polypeptide, Gamma-trace, Post-gamma-globulin, CST3
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RD191009100 96 wells (1 kit)
PubMed Product Details
Technical Data

Successful participation in EQA!

We are pleased to announce that we have successfully participated in the External Quality Assessment (INSTAND, survey of March 20, 2019), being involved in determination of Cystatin C.

Please find the Certificate in Docs or see article in RnD News.

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate, Urine, Cerebrospinal fluid

Sample Requirements

10 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

200–10 000 ng/ml

Limit of Detection

0.25 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 3.4 %

Inter-assay (Run-to-Run)

n = 5; CV = 6.9 %

Spiking Recovery

95.0 %

Dilutation Linearity

97.8 %

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
  • monkey Yes (recommended dilution 1:400)
Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 2 hours
  • The kit measures total cystatin C in serum, plasma (EDTA, citrate, heparin), urine and cerebrospinal fluid
  • Assay format is 96 wells
  • Quality Controls are human serum or human urine native protein based. No animal sera are used
  • Standard is purified native protein based
  • Components of the kit are provided ready to use or concentrated
  • Convenient for automatization

Research topic

Neural tissue markers, Renal disease

Summary

Cysteine proteinase inhibitors, cystatins superfamily, have been identified in animals, plants
and protozoa. All cystatins inactivate lysosomal cysteine proteinases, e.g. cathepsin B, H, K, L
and S as well as some structurally related plant proteinases, such as papain and actinidin.
Human cystatin C is produced at a constant rate by all nucleated body cells and occurs in all
body fluids abundantly. It is a non-glycosilated basic single-chain protein consisting of 120
amino acids with a molecular weight of 13.36 kDa and is characterized by two disulfide bonds
in the carboxy-terminal region. The protein is encoded by the CS73 gene located on the short
arm of chromosome 20.

Biological function of human cystatin C, and its role in various pathological states, has been the
subject of numerous studies. Imbalance between cystatin C and cysteine proteinases is
associated with diseases such as inflammation, renal failure, cancer, Alzheimer disease,
multiple sclerosis and hereditary cystatin C amyloid angiopathy. Its increased level has been
found in patients with autoimune diseases, with colorectal tumors and metastases, patients
with inflammation and in patients on dialysis. Serum cystatin C concentration correlates
negatively with glomerular filtration rate (GFR) as well as or better than creatinine, therefore
was recently proposed as a new, very sensitive, marker of changes in GFR.

On the other hand, low levels of cystatin C come along the breakdown of the elastic laminae
and, subsequently, the atherosclerosis and abdominal aortic aneurysm, as indicate latest
publications. Results make evident association of cystatin C levels with the incidence of
myocardial infarction, coronary death and angina pectoris. Furthermore, cystatin C correlates
with triglycerides, LDL-cholesterol, BMI and age of individuals. Thus, low concentration of
cystatin C presents a risk factor for secondary cardiovascular events.

Product References (59)

References

  • Adanir T, Aksun M, Cirit M, Alkan Taşli F, Sahin O, Kestelli M, AydinKantaroğlu T, Köseoğlu M, Sencan A, Karahan N. The renal effect of replacementfluids in controlled severe hemorrhagic shock: an experimental study. Ulus TravmaAcil Cerrahi Derg. 2009 Sep;15(5):423-32. PubMed PMID: 19779981. See more on PubMed
  • Agarwal SK, Saikia UK, Sarma D, Devi R. Assessment of Glomerular and TubularFunction in the Evaluation of Diabetic Nephropathy: A Cross-sectional Study.Indian J Endocrinol Metab. 2018 Jul-Aug;22(4):451-456. doi:10.4103/ijem.IJEM_303_17. PubMed PMID: 30148087; PubMed Central PMCID:PMC6085973. See more on PubMed
  • Albayrak S, Ordu S, Ozhan H, Yazici M, Aydin M, Alemdar R, Kaya A. Effect ofolmesartan medoxomil on cystatin C level, left ventricular hypertrophy anddiastolic function. Blood Press. 2009;18(4):187-91. doi:10.1080/08037050903047236. PubMed PMID: 19521888. See more on PubMed
  • Androulakis E, Papageorgiou N, Lioudaki E, Chatzistamatiou E, Zacharia E,Kallikazaros I, Tousoulis D. Subclinical Organ Damage in White-Coat Hypertension:The Possible Role of Cystatin C. J Clin Hypertens (Greenwich). 2017Feb;19(2):190-197. doi: 10.1111/jch.12882. Epub 2016 Jul 21. PubMed PMID:27440165. See more on PubMed
  • Babelova A, Avaniadi D, Jung O, Fork C, Beckmann J, Kosowski J, Weissmann N,Anilkumar N, Shah AM, Schaefer L, Schröder K, Brandes RP. Role of Nox4 in murine models of kidney disease. Free Radic Biol Med. 2012 Aug 15;53(4):842-53. doi:10.1016/j.freeradbiomed.2012.06.027. Epub 2012 Jun 27. PubMed PMID: 22749956. See more on PubMed
  • Barrientos LG, Rollin PE. Release of cellular proteases into the acidicextracellular milieu exacerbates Ebola virus-induced cell damage. Virology. 2007 Feb 5;358(1):1-9. Epub 2006 Sep 18. PubMed PMID: 16982079. See more on PubMed
  • Bayram A, Esmaoglu A, Akin A, Baskol G, Aksu R, Bicer C, Demirtas A, MutluayR, Boyaci A. The effects of intraoperative infusion of dexmedetomidine on earlyrenal function after percutaneous nephrolithotomy. Acta Anaesthesiol Scand. 2011 May;55(5):539-44. doi: 10.1111/j.1399-6576.2011.02427.x. PubMed PMID: 21827441. See more on PubMed
  • Bhattacharyya S, Wang W, Graham LV, Varga J. A20 suppresses canonicalSmad-dependent fibroblast activation: novel function for an endogenousinflammatory modulator. Arthritis Res Ther. 2016 Oct 3;18(1):216. PubMed PMID:27716397; PubMed Central PMCID: PMC5048449. See more on PubMed
  • Chen X, Chen Y, Wei Q, Ou R, Cao B, Zhao B, Shang HF. Assessment of a multiplebiomarker panel for diagnosis of amyotrophic lateral sclerosis. BMC Neurol. 2016 Sep 15;16:173. doi: 10.1186/s12883-016-0689-x. PubMed PMID: 27634542; PubMedCentral PMCID: PMC5024522. See more on PubMed
  • Chung MY, Jun DW, Sung SA. Diagnostic value of cystatin C for predicting acutekidney injury in patients with liver cirrhosis. Korean J Hepatol. 2010Sep;16(3):301-7. doi: 10.3350/kjhep.2010.16.3.301. PubMed PMID: 20924213; PubMed Central PMCID: PMC3304597. See more on PubMed
  • Dikovskaya MA, Trunov AN, Chernykh VV, Korolenko TA. Cystatin C andlactoferrin concentrations in biological fluids as possible prognostic factors ineye tumor development. Int J Circumpolar Health. 2013 Aug 5;72. doi:10.3402/ijch.v72i0.21087. eCollection 2013. PubMed PMID: 23984285; PubMed CentralPMCID: PMC3753133. See more on PubMed
  • Domingueti CP, Fuzatto JA, Fóscolo RB, Reis JS, Dusse LM, Carvalho MDG, Gomes KB, Fernandes AP. Association between Von Willebrand factor, disintegrin andmetalloproteinase with thrombospondin type 1 motif member 13, d-Dimer andcystatin C levels with retinopathy in type 1 diabetes mellitus. Clin Chim Acta.2016 Aug 1;459:1-4. doi: 10.1016/j.cca.2016.05.011. Epub 2016 May 18. PubMedPMID: 27208743. See more on PubMed
  • El Shebini SM, Moaty MIA, Fouad S, Ahmed NH, Tapozada ST. Obesity RelatedMetabolic Disorders and Risk of Renal Disease: Impact of Hypocaloric Diet andAvena Sativa Supplement. Open Access Maced J Med Sci. 2018 Jul 29;6(8):1376-1381.doi: 10.3889/oamjms.2018.292. eCollection 2018 Aug 20. PubMed PMID: 30159060;PubMed Central PMCID: PMC6108808. See more on PubMed
  • Esezobor CI, Iroha E, Oladipo O, Onifade E, Soriyan OO, Akinsulie AO, TemiyeEO, Ezeaka C. Kidney function of HIV-infected children in Lagos, Nigeria: usingFiller's serum cystatin C-based formula. J Int AIDS Soc. 2010 May 18;13:17. doi: 10.1186/1758-2652-13-17. PubMed PMID: 20482807; PubMed Central PMCID: PMC2888781. See more on PubMed
  • Gashenko EA, Lebedeva VA, Brak IV, Tsykalenko EA, Vinokurova GV, Korolenko TA.Evaluation of serum procathepsin B, cystatin B and cystatin C as possiblebiomarkers of ovarian cancer. Int J Circumpolar Health. 2013 Aug 5;72. doi:10.3402/ijch.v72i0.21215. eCollection 2013. PubMed PMID: 23986888; PubMed CentralPMCID: PMC3754495. See more on PubMed
  • Han J, Gao Y, Guo Q, Su D, Yan B, Peng L, Du Y, Li K, Wang G. Cross-sectional study on the relationship between the level of serum cystatin C and bloodpressure reverse dipping in hypertensive patients. BMJ Open. 2016 Sep2;6(9):e011166. doi: 10.1136/bmjopen-2016-011166. PubMed PMID: 27591018; PubMedCentral PMCID: PMC5020748. See more on PubMed
  • Herath TDK, Darveau RP, Seneviratne CJ, Wang CY, Wang Y, Jin L. Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts. Sci Rep. 2016Aug 19;6:29829. doi: 10.1038/srep29829. PubMed PMID: 27538450; PubMed CentralPMCID: PMC4990928. See more on PubMed
  • Hilmi IA, Peng Z, Planinsic RM, Damian D, Dai F, Tyurina YY, Kagan VE, Kellum JA. N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury inpatients undergoing orthotopic liver transplantation. Nephrol Dial Transplant.2010 Jul;25(7):2328-33. doi: 10.1093/ndt/gfq077. Epub 2010 Feb 22. PubMed PMID:20179007. See more on PubMed
  • Hossain MA, Emara M, El Moselhi H, Shoker A. Comparing measures of cystatin C in human sera by three methods. Am J Nephrol. 2009;29(5):381-91. doi:10.1159/000168486. Epub 2008 Oct 31. PubMed PMID: 18974639. See more on PubMed
  • Kobayashi T, Yoshida T, Fujisawa T, Matsumura Y, Ozawa T, Yanai H, Iwasawa A, Kamachi T, Fujiwara K, Kohno M, Tanaka N. A metabolomics-based approach forpredicting stages of chronic kidney disease. Biochem Biophys Res Commun. 2014 Mar7;445(2):412-6. doi: 10.1016/j.bbrc.2014.02.021. Epub 2014 Feb 12. PubMed PMID:24530913. See more on PubMed
  • Korolenko TA, Filatova TG, Cherkanova MS, Khalikova TA, Bravve IIu.[Cystatins: cysteine proteases regulation and disturbances in tumors andinflammation]. Biomed Khim. 2008 Mar-Apr;54(2):210-7. Russian. PubMed PMID:18522223. See more on PubMed
  • Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE,O'Connor MF, Konczal DJ, Trevino S, Devarajan P, Murray PT. Urinary cystatin C asan early biomarker of acute kidney injury following adult cardiothoracic surgery.Kidney Int. 2008 Oct;74(8):1059-69. doi: 10.1038/ki.2008.341. Epub 2008 Jul 23.PubMed PMID: 18650797; PubMed Central PMCID: PMC2745082. See more on PubMed
  • Kwon WS, Kim TS, Nahm CH, Moon Y, Kim JJ. Aberrant cystatin-C expression inblood from patients with breast cancer is a suitable marker for monitoring tumor burden. Oncol Lett. 2018 Nov;16(5):5583-5590. doi: 10.3892/ol.2018.9380. Epub2018 Sep 3. PubMed PMID: 30344712; PubMed Central PMCID: PMC6176264. See more on PubMed
  • Lapinski TW, Parfieniuk A, Rogalska-Plonska M, Czajkowska J, Flisiak R.Prevalence of cryoglobulinaemia in hepatitis C virus- and hepatitis C virus/humanimmunodeficiency virus-infected individuals: implications for renal function.Liver Int. 2009 Sep;29(8):1158-61. doi: 10.1111/j.1478-3231.2009.02052.x. Epub2009 Jul 7. PubMed PMID: 19602133. See more on PubMed
  • Liu X, Zeng B, Xu J. Alteration of cystatin C in cerebrospinal fluid ofpatients with sciatica revealed by a proteomical approach. Saudi Med J. 2005Nov;26(11):1699-704. PubMed PMID: 16311651. See more on PubMed
  • Liu XD, Zeng BF, Xu JG, Zhu HB, Xia QC. Proteomic analysis of thecerebrospinal fluid of patients with lumbar disk herniation. Proteomics. 2006Feb;6(3):1019-28. PubMed PMID: 16372267. See more on PubMed
  • Liu Y, El-Achkar TM, Wu XR. Tamm-Horsfall protein regulates circulating andrenal cytokines by affecting glomerular filtration rate and acting as a urinarycytokine trap. J Biol Chem. 2012 May 11;287(20):16365-78. doi:10.1074/jbc.M112.348243. Epub 2012 Mar 27. PubMed PMID: 22451664; PubMed Central PMCID: PMC3351356. See more on PubMed
  • Malamitsi-Puchner A, Briana DD, Kontara L, Boutsikou M, Baka S, Hassiakos D,Marmarinos A, Gourgiotis D. Serum cystatin C in pregnancies with normal andrestricted fetal growth. Reprod Sci. 2007 Jan;14(1):37-42. PubMed PMID: 17636214. See more on PubMed
  • Malyszko J, Przybylowski P, Koc-Zorawska E, Iaina-Levin N, Sadowski J,Mysliwiec M, Malyszko JS. Copeptin in relation to New York Heart Associationclass in heart transplant recipients and kidney transplant recipients. TransplantProc. 2010 Dec;42(10):4259-62. doi: 10.1016/j.transproceed.2010.09.031. PubMedPMID: 21168678. See more on PubMed
  • Mares J, Kanovsky P, Herzig R, Stejskal D, Vavrouskova J, Hlustik P, VranovaH, Burval S, Zapletalova J, Pidrman V, Obereigneru R, Suchy A, Vesely J,Podivinsky J, Urbanek K. New laboratory markers in diagnosis of alzheimerdementia. Neurol Res. 2009 Dec;31(10):1056-9. doi: 10.1179/174313209X385536. Epub2009 Jul 8. PubMed PMID: 19589198. See more on PubMed
  • Mares J, Kanovsky P, Herzig R, Stejskal D, Vavrouskova J, Hlustik P, VranovaH, Burval S, Zapletalova J, Pidrman V, Obereigneru R, Suchy A, Vesely J,Podivinsky J, Urbanek K. The assessment of beta amyloid, tau protein and cystatinC in the cerebrospinal fluid: laboratory markers of neurodegenerative diseases.Neurol Sci. 2009 Feb;30(1):1-7. doi: 10.1007/s10072-008-0005-7. Epub 2009 Jan 20.PubMed PMID: 19153649. See more on PubMed
  • Medeiros T, do Rosário NF, Gama NA, Mérida LAD, Storch AS, Ferraz L, de FátimaLopes P, da Silva AA, Almeida JR. Metabolic syndrome components and estimatedglomerular filtration rate based on creatinine and/or cystatin C in young adults:A gender issue? Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S351-S357. doi:10.1016/j.dsx.2017.03.015. Epub 2017 Mar 6. PubMed PMID: 28284908. See more on PubMed
  • Miele G, Seeger H, Marino D, Eberhard R, Heikenwalder M, Stoeck K, Basagni M, Knight R, Green A, Chianini F, Wüthrich RP, Hock C, Zerr I, Aguzzi A. Urinaryalpha1-antichymotrypsin: a biomarker of prion infection. PLoS One.2008;3(12):e3870. doi: 10.1371/journal.pone.0003870. Epub 2008 Dec 5. PubMedPMID: 19057641; PubMed Central PMCID: PMC2586086. See more on PubMed
  • Mlodawska E, Tomaszuk-Kazberuk A, Lopatowska P, Waszkiewicz E,Bachorzewska-Gajewska H, Malyszko J, Michniewicz E, Dobrzycki S, Musial WJ.Matrix Metalloproteinase Neutrophil Gelatinase-Associated Lipocalin ComplexPredicts Atrial Fibrillation Recurrence after Electrical Cardioversion in ObesePatients. Cardiorenal Med. 2016 Nov;7(1):11-20. Epub 2016 Aug 12. PubMed PMID:27994598; PubMed Central PMCID: PMC5159726. See more on PubMed
  • Musiol K, Sobol-Milejska G, Nowotka Ł, Torba K, Kniażewska M, Wos H. Renalfunction in children treated for central nervous system malignancies. Childs NervSyst. 2016 Aug;32(8):1431-40. doi: 10.1007/s00381-016-3130-2. Epub 2016 Jun 21.PubMed PMID: 27325303; PubMed Central PMCID: PMC4967096. See more on PubMed
  • Nakae H, Igarashi T, Tajimi K, Noguchi A, Takahashi I, Tsuchida S, TakahashiT, Asanuma Y. A case report of pediatric fulminant hepatitis treated with plasma diafiltration. Ther Apher Dial. 2008 Aug;12(4):329-32. doi:10.1111/j.1744-9987.2008.00595.x. PubMed PMID: 18789121. See more on PubMed
  • Ni X, Gu Y, Yu H, Wang S, Chen Y, Wang X, Yuan X, Jia W. Serum Adipocyte FattyAcid-Binding Protein 4 Levels Are Independently Associated with RadioisotopeGlomerular Filtration Rate in Type 2 Diabetic Patients with Early DiabeticNephropathy. Biomed Res Int. 2018 May 27;2018:4578140. doi: 10.1155/2018/4578140.eCollection 2018. PubMed PMID: 29992142; PubMed Central PMCID: PMC5994326. See more on PubMed
  • Pasa S, Bayramli G, Atasoy A, Karul A, Ertug S, Ozensoy Toz S. Evaluation ofserum cystatin-C in dogs with visceral leishmaniasis. Vet Res Commun. 2009Aug;33(6):529-34. doi: 10.1007/s11259-008-9200-5. Epub 2009 Jan 13. PubMed PMID: 19140021. See more on PubMed
  • Przybylowski P, Malyszko J, Malyszko JS. Serum neutrophilgelatinase-associated lipocalin correlates with kidney function in heartallograft recipients. Transplant Proc. 2010 Jun;42(5):1797-802. doi:10.1016/j.transproceed.2010.02.079. PubMed PMID: 20620526. See more on PubMed
  • Saito T, Urushihara M, Kotani Y, Kagami S, Kobori H. Increased urinaryangiotensinogen is precedent to increased urinary albumin in patients with type 1diabetes. Am J Med Sci. 2009 Dec;338(6):478-80. doi:10.1097/MAJ.0b013e3181b90c25. PubMed PMID: 19884815; PubMed Central PMCID:PMC2795783. See more on PubMed
  • Santana-Santos E, Gowdak LH, Gaiotto FA, Puig LB, Hajjar LA, Zeferino SP,Drager LF, Shimizu MH, Bortolotto LA, De Lima JJ. High dose of N-acetylcysteinprevents acute kidney injury in chronic kidney disease patients undergoingmyocardial revascularization. Ann Thorac Surg. 2014 May;97(5):1617-23. doi:10.1016/j.athoracsur.2014.01.056. Epub 2014 Mar 20. PubMed PMID: 24657033. See more on PubMed
  • Shaarawy M, Fathy SA, Mehany NL, Hindy OW. Circulating levels ofosteoprotegerin and receptor activator of NF-kappaB ligand in patients withchronic renal failure. Clin Chem Lab Med. 2007;45(11):1498-503. PubMed PMID:17970704. See more on PubMed
  • Stejskal D, Vavrousková J, Mares J, Urbánek K. Applications of new laboratory marker assays in neurological diagnoses - a pilot study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):265-6. PubMed PMID: 16601767. See more on PubMed
  • Straface E, Matarrese P, Gambardella L, Vona R, Sgadari A, Silveri MC, MalorniW. Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study. FEBS Lett. 2005 May 23;579(13):2759-66. Epub2005 Apr 19. PubMed PMID: 15907478. See more on PubMed
  • Taleb S, Cancello R, Clément K, Lacasa D. Cathepsin s promotes humanpreadipocyte differentiation: possible involvement of fibronectin degradation.Endocrinology. 2006 Oct;147(10):4950-9. Epub 2006 Jul 6. PubMed PMID: 16825321. See more on PubMed
  • Taleb S, Cancello R, Poitou C, Rouault C, Sellam P, Levy P, Bouillot JL,Coussieu C, Basdevant A, Guerre-Millo M, Lacasa D, Clement K. Weight loss reducesadipose tissue cathepsin S and its circulating levels in morbidly obese women. J Clin Endocrinol Metab. 2006 Mar;91(3):1042-7. Epub 2006 Jan 4. PubMed PMID:16394095. See more on PubMed
  • Taleb S, Lacasa D, Bastard JP, Poitou C, Cancello R, Pelloux V, Viguerie N,Benis A, Zucker JD, Bouillot JL, Coussieu C, Basdevant A, Langin D, Clement K.Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis. FASEB J.2005 Sep;19(11):1540-2. Epub 2005 Jun 28. PubMed PMID: 15985526. See more on PubMed
  • Trenchevska O, Nedelkov D. Targeted quantitative mass spectrometricimmunoassay for human protein variants. Proteome Sci. 2011 Apr 8;9(1):19. doi:10.1186/1477-5956-9-19. PubMed PMID: 21477312; PubMed Central PMCID: PMC3080279. See more on PubMed
  • Tumminello FM, Flandina C, Crescimanno M, Leto G. Circulating cathepsin K and cystatin C in patients with cancer related bone disease: clinical and therapeuticimplications. Biomed Pharmacother. 2008 Feb;62(2):130-5. Epub 2007 Jul 30. PubMedPMID: 17728092. See more on PubMed
  • von Eynatten M, Liu D, Hock C, Oikonomou D, Baumann M, Allolio B, KorosoglouG, Morcos M, Campean V, Amann K, Lutz J, Heemann U, Nawroth PP, Bierhaus A,Humpert PM. Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes. Diabetes. 2009 Sep;58(9):2093-9. doi: 10.2337/db09-0204. Epub2009 Jun 9. PubMed PMID: 19509019; PubMed Central PMCID: PMC2731516. See more on PubMed
  • Woischnik M, Bauer A, Aboutaam R, Pamir A, Stanzel F, de Blic J, Griese M.Cathepsin H and napsin A are active in the alveoli and increased in alveolarproteinosis. Eur Respir J. 2008 Jun;31(6):1197-204. doi:10.1183/09031936.00081207. Epub 2008 Jan 23. PubMed PMID: 18216060. See more on PubMed
  • Yang X, Wang H, Wang Z, Dong M. Alteration and significance of serum cardiactroponin I and cystatin C in preeclampsia. Clin Chim Acta. 2006Dec;374(1-2):168-9. Epub 2006 Jul 14. PubMed PMID: 16914129. See more on PubMed
  • Yang Y, Liu S, Qin Z, Cui Y, Qin Y, Bai S. Alteration of cystatin C levels in cerebrospinal fluid of patients with Guillain-Barré Syndrome by a proteomicalapproach. Mol Biol Rep. 2009 Apr;36(4):677-82. doi: 10.1007/s11033-008-9228-1.Epub 2008 Mar 29. PubMed PMID: 18373213. See more on PubMed
  • Yavuz S, Anarat A, Bayazıt AK. Assessment of cystatin C and cystatin C-basedGFR formulas in reflux nephropathy. J Pediatr Urol. 2014 Apr;10(2):262-7. doi:10.1016/j.jpurol.2013.08.010. Epub 2013 Sep 15. PubMed PMID: 24128877. See more on PubMed
  • Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, Kalmowitz B, Wells M,Guerrero M, Asara JM, Libermann TA, Afdhal NH. Serum proteomics and biomarkers inhepatocellular carcinoma and chronic liver disease. Clin Cancer Res. 2008 Jan15;14(2):470-7. doi: 10.1158/1078-0432.CCR-07-0586. PubMed PMID: 18223221. See more on PubMed
  • Madise-Wobo AD, Gbelee OH, Solarin A, Animasahun BA, Njokanma OF. Serumcystatin C levels in Healthy Nigerian neonates: Is there a need for normativevalues in Nigerian babies? Saudi J Kidney Dis Transpl. 2017Nov-Dec;28(6):1247-1255. doi: 10.4103/1319-2442.220881. PubMed PMID: 29265035. See more on PubMed
  • Mutlu M, Vuralkan E, Akin I, Firat H, Ardic S, Akaydin S, Miser E. Alteration of serum levels of inflammatory cytokines and polysomnographic indices afteruvulopalatal flap surgery in obstructive sleep apnea. Ear Nose Throat J. 2017Feb;96(2):65-68. PubMed PMID: 28231365. See more on PubMed
  • Bielecka-Dabrowa A, Sakowicz A, Pietrucha T, Misztal M, Chruściel P, Rysz J,Banach M. The profile of selected single nucleotide polymorphisms in patientswith hypertension and heart failure with preserved and mid-range ejectionfraction. Sci Rep. 2017 Aug 21;7(1):8974. doi: 10.1038/s41598-017-09564-9. PubMedPMID: 28827564; PubMed Central PMCID: PMC5566797. See more on PubMed
  • Lim TKY, Anderson KM, Hari P, Di Falco M, Reihsen TE, Wilcox GL, Belani KG,LaBoissiere S, Pinto MR, Beebe DS, Kehl LJ, Stone LS. Evidence for a Role ofNerve Injury in Painful Intervertebral Disc Degeneration: A Cross-SectionalProteomic Analysis of Human Cerebrospinal Fluid. J Pain. 2017Oct;18(10):1253-1269. doi: 10.1016/j.jpain.2017.06.002. Epub 2017 Jun 24. PubMed PMID: 28652204; PubMed Central PMCID: PMC5614853. See more on PubMed
Summary References (20)

References to Cystatin C

  • Bokenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C--a new marker of glomerular filtration rate in children independent of age and height. Pediatrics. 1998 May;101 (5):875-81
  • Delanaye P, Cavalier E, Krzesinski JM. Cystatin C, renal function, and cardiovascular risk. Ann Intern Med. 2008 Feb 19;148 (4):323
  • Deng A, Irizarry MC, Nitsch RM, Growdon JH, Rebeck GW. Elevation of cystatin C in susceptible neurons in Alzheimer's disease. Am J Pathol. 2001 Sep;159 (3):1061-8
  • Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002 Aug;40 (2):221-6
  • Ekiel I, Abrahamson M, Fulton DB, Lindahl P, Storer AC, Levadoux W, Lafrance M, Labelle S, Pomerleau Y, Groleau D, LeSauteur L, Gehring K. NMR structural studies of human cystatin C dimers and monomers. J Mol Biol. 1997 Aug 15;271 (2):266-77
  • Luc G, Bard JM, Lesueur C, Arveiler D, Evans A, Amouyel P, Ferrieres J, Juhan-Vague I, Fruchart JC, Ducimetiere P. Plasma cystatin-C and development of coronary heart disease: The PRIME Study. Atherosclerosis. 2006 Apr;185 (2):375-80
  • Macisaac RJ, Tsalamandris C, Thomas MC, Premaratne E, Panagiotopoulos S, Smith TJ, Poon A, Jenkins MA, Ratnaike SI, Power DA, Jerums G. Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods. Diabetologia. 2006 Jul;49 (7):1686-9
  • Mojiminiyi OA, Abdella N. Evaluation of cystatin C and beta-2 microglobulin as markers of renal function in patients with type 2 diabetes mellitus. J Diabetes Complications. 2003 May-Jun;17 (3):160-8
  • Moran A, Katz R, Smith NL, Fried LF, Sarnak MJ, Seliger SL, Psaty B, Siscovick DS, Gottdiener JS, Shlipak MG. Cystatin C concentration as a predictor of systolic and diastolic heart failure. J Card Fail. 2008 Feb;14 (1):19-26
  • Muntner P, Mann D, Winston J, Bansilal S, Farkouh ME. Serum cystatin C and increased coronary heart disease prevalence in US adults without chronic kidney disease. Am J Cardiol. 2008 Jul 1;102 (1):54-7
  • Muntner P, Winston J, Uribarri J, Mann D, Fox CS. Overweight, obesity, and elevated serum cystatin C levels in adults in the United States. Am J Med. 2008 Apr;121 (4):341-8
  • Mussap M, Plebani M. Biochemistry and clinical role of human cystatin C. Crit Rev Clin Lab Sci. 2004;41 (5-6):467-550
  • Nakashima I, Fujinoki M, Fujihara K, Kawamura T, Nishimura T, Nakamura M, Itoyama Y. Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis. Ann Neurol. 2007 Aug;62 (2):197-200; discussion 205
  • Ortiz F, Harmoinen A, Paavonen T, Koskinen P, Gronhagen-Riska C, Honkanen E. Is Cystatin C more sensitive than creatinine in detecting early chronic allograft nephropathy?. Clin Nephrol. 2008 Jul;70 (1):18-25
  • Parikh NI, Hwang SJ, Yang Q, Larson MG, Guo CY, Robins SJ, Sutherland P, Benjamin EJ, Levy D, Fox CS. Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study). Am J Cardiol. 2008 Nov 1;102 (9):1194-8
  • Perlemoine C, Beauvieux MC, Rigalleau V, Baillet L, Barthes N, Derache P, Gin H. Interest of cystatin C in screening diabetic patients for early impairment of renal function. Metabolism. 2003 Oct;52 (10):1258-64
  • Premaratne E, MacIsaac RJ, Finch S, Panagiotopoulos S, Ekinci E, Jerums G. Serial measurements of cystatin C are more accurate than creatinine-based methods in detecting declining renal function in type 1 diabetes. Diabetes Care. 2008 May;31 (5):971-3
  • Risch L, Blumberg A, Huber A. Rapid and accurate assessment of glomerular filtration rate in patients with renal transplants using serum cystatin C. Nephrol Dial Transplant. 1999 Aug;14 (8):1991-6
  • Samouilidou EC, Grapsa E. Relationship of serum cystatin C with C-reactive protein and apolipoprotein A1 in patients on hemodialysis. Ren Fail. 2008;30 (7):711-5
  • Servais A, Giral P, Bernard M, Bruckert E, Deray G, Isnard Bagnis C. Is serum cystatin-C a reliable marker for metaboli
Related Products Docs