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Manufactured by BioVendor

Mouse Amyloid beta 42 ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Aß, A beta
  • Species:Mouse
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New RIG012R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Tissue homogenates, Cerebrospinal fluid, Cell culture supernatant

Sample Requirements

100 µL/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box). Do not freeze.

Calibration Range

3.12-200 pg/mL

Limit of Detection

<3 pg/mL

Summary

Features

  • The total assay time is 4 hours

Summary

Amyloid beta (Aβ or A beta) is a protein fragment of 39–43 amino acids that is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Aβ is formed after sequential cleavage of the amyloid precursor protein (APP, transmembrane glycoprotein) by the β- and γ-secretases. . The major species generated are Aβ40 and Aβ42. The latter is more hydrophobic and more apt to aggregate and thus is considered to be primarily pathogenic, consistent with the phenotype of the major familial ADcausing mutations. Increases in either total Aβ levels or the relative concentration of the 42-amino acid form have been implicated in the pathogenesis of both familial and sporadic Alzheimer's di­sease. The 42-mers are the most amyloidogenic form of the peptide.

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