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22 \ 04 \ 2019

BioVendor R&D new products April 2019

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Dear customer, we would like to introduce our new products from January 2019 and hope you will find them interesting. Below is a list of events, in which we plan to participate in 2019:

AACC 2019 (04 \ 08 \ 2019 - 08 \ 08 \ 2019 – Anaheim)
MEDICA 2019 (18 \ 11 \ 2019 - 21 \ 11 \ 2019 – Düsseldorf)

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NEW miREIA KITS

CAT. NO. STATUS NAME ASSAY FORMAT
RDM0028H New hsa-miR-26b-5p miREIA miREIA – miRNA enzyme immunoassay
RDM0020H New hsa-miR-92a-3p miREIA miREIA – miRNA enzyme immunoassay
RDM0017H New hsa-miR-155-5p miREIA miREIA – miRNA enzyme immunoassay
RDM0014H New hsa-miR-222-3p miREIA miREIA – miRNA enzyme immunoassay
RDM0026H New mmu-miR-7052-5p miREIA miREIA – miRNA enzyme immunoassay

Featured product: hsa-miR-155-5p miREIA

It is well-known that miR-155-5p is a proinflammatory, oncogenic miRNA, often associated with inflammation, cancer, and cardiovascular diseases.


Immune system

  • mainly expressed in the thymus and spleen
  • highly expressed in activated B and T cells as well as in macrophages miR-155-5p controls the function of lymphocytes and dendritic cells and is critical for normal immune function
  • 140 target genes encode for immunomodulatory proteins, tumor-suppressor proteins, and inflammatory-related proteins

 

Oncology

  • in high levels in several solid tumors such as lung cancer, breast cancer, thyroid carcinoma, cervical cancer, and pancreatic cancer 
  • an indicator of poor prognosis for patients with these tumors. 
  • Overexpressed in hematological malignancies, such as chronic lymphocytic leukemia (CLL) pathogenesis and is a promising, independent biomarker of unfavorable prognosis in CLL.

 

Gastrointestinal tract

  • Highly expressed during Helicobacter pylori infection
  • Increased expression in patients with inflammatory bowel disease (IBD) 
  • Increased expression in patients with colorectal cancer (CRC).

 

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For this and more BioVendor miREIA kits, please visit www.biovendor.com/mirna.

microRNAs (miRNAs) are a class of single-stranded non-coding RNA molecules with a length of 19-23 nucleotides. They play a role in negative post-transcriptional regulation by binding to complementary sequences on mRNA and blocking translation into protein. 

miREIA is a BioVendor proprietary method based on the combination of immunoassay and molecular biological principles. The main advantage is the quantitative determination of miRNA concentrations.

See more about hsa-miR-155-5p miREIA.



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NEW IMMUNOASSAYS

CAT. NO. SPECIES NAME ASSAY FORMAT
RD191470200R Human MyBPC3 ELISA Sandwich ELISA, Biotin-labelled antibody
RD191470200R Human MyBPC3 ELISA Sandwich ELISA, Biotin-labelled antibody

Featured product: HUMAN MYOSIN BINDING PROTEIN-C3 (MyBPC3)  ELISA

Cardiac MyBP-C may be more useful than the gold standard biomarker Cardiac Troponin I

Blood levels of the current gold standard cardiac biomarkers are very low during the initial stages of myocardial infarction (MI), making early diagnosis difficult. Plasma levels of MyBPC3 are significantly elevated in MI patients. MyBPC3 levels increase from baseline at 3 hours after MI and peak at 6 hours. This is faster than for Cardiac Troponin I, which is normally detected 6-12 hours after the onset of MI. 

Cardiac MyBPC (cMyBP-C, MyBPC3) is a 140 kDa structural protein that is present only in the heart. It is phosphorylated by several kinases. Phosphorylation of MyBPC3 regulates myocardial function and confers resistance to proteolysis, preserving cardiac function post-myocardial infarction. 

Dephosphorylation at Ser-273 and Ser-282 facilitates MyBPC3 degradation and release of a 40 kDa N-terminal fragment (C0C1f). This C0C1f fragment is pathogenic within cardiac tissue and it is released into the circulation. It was later established in vivo that the C0C1f fragment could cause cardiac dysfunction and heart failure. 

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Importantly, it was shown that plasma MyBPC3 levels are significantly raised in humans with hypertrophic cardiomyopathy undergoing trans-coronary ablation of septal hypertrophy.

 

  •  Validated for human serum and citrate plasma 
  • Excellent sensitivity (LOD 1.74 pg/ml)

  

See more about  MyBPC3 Human ELISA

RELATED PRODUCTS

RD172470100 Myosin-binding protein C cardiac-type Human E. coli


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NEW PROTEINS


CAT. NO. SPECIES NAME SIZE SOURCE
RD272587025 Mouse Adiponectin, Tag free 0.025 mg HEK293
RD272587100 Mouse Adiponectin, Tag free 0.1 mg HEK293
RD172091025 Human Adiponectin, Trimeric form 0.025 mg HEK293
RD1725740100 Human CCL17 0.1 mg E. coli
RD162034100 Human Clusterin NATIVE 0.1 mg Human serum
RD176034100 Human Clusterin, Tag free 0.1 mg HEK293
RD172566025 Human Interleukin-2 0.025 mg E. coli
RD172566100 Human Interleukin-2 0.1 mg E. coli
RD172571100 Human Interleukin-7 0.1 mg E. coli
RD172058025 Human Myostatin Propeptide, Tag free 0.025 mg E. coli
RD172562025 Human Neurofilament light polypeptide 0.025 mg E. coli

Featured product: HUMAN CCL17, E. COLI

Chemokine (C-C motif) ligand 17 (CCL17)/thymus and activation-related chemokine (TARC) is a CC chemokine secreted by PBMCs and various subsets of monocyte-derived dendritic cells, including thymic dendritic cells and endothelial cells. CCL17 interacts with CCR4 and CCR8 to induce the chemoattraction of activated Th2 cells, basophils, and NK cells. This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1. 

CCL17 is associated with various mechanisms of the immune system and plays vital roles in such disorders as allergen-induced asthma and autoimmune diseases.

BioVendor Human CCL17 is a recombinant protein expressed in E.coli

Total 78 AA. MW: 15 kDa (calculated). UniProtKB acc.no. Q92583 (Ala24-Ser94). N-terminal His-tag (7 extra AA). Endotoxin < 0.1 EU/µg. Protein identity was confirmed by LC-MS/MS.

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14% SDS-PAGE separation of Human CCL17, E. coli:

1. M.W. marker – 14, 21, 31, 45, 66, 97 kDa

2. Reduced and boiled sample, 2.5 μg/lane

3. Non-reduced and non-boiled sample, 2.5 μg/lane


See more about Human CCL17, E. coli


 




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NEW ANTIBODIES


CAT. NO. SPECIES NAME REACTIVE SP. SIZE
RD1820261003G6 Anti-Human Cardiotrophin-1  Mouse Monoclonal Antibody, Clone: 3G6D9 0.1 mg
RD1820341008H4-01 Anti-Human Clusterin Mouse Monoclonal Antibody, Clone: 8H4 0.1 mg
RD484488100 Anti-Canine Fibroblast Growth Factor 21, Tag free Sheep Polyclonal Antibody 0.1 mg

Featured product: ANTI-HUMAN CLUSTERIN MOUSE MONOCLONAL ANTIBODY, CLONE: 8H4

Innovated versions of highly popular with customers mouse MAb anti-human Clusterin, clone 8H4 is newly produced in vitro and isolated from the cell culture supernatant. Clusterin (Apolipoprotein J, ApoJ) is an extracellular chaperone protecting cells from stress induced by degraded and misfolded protein precipitates. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin, and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition.  12183

Clusterin is up- or downregulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity, and others

Applications: ELISAClusterin is a 75–80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid, but truncated forms targeted to the nucleus have also been identified. Across a broad range of species, clusterin shows 70% to 80% of sequence homology. It is ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen.

See more about Anti-Human Clusterin, Mouse MAb, Clone: 8H4

RELATED PRODUCTS

RD491034200R Clusterin Canine ELISA
RD194034200R Clusterin Human ELISA
RD391034200CS Clusterin Rat ELISA
RD472034100 Clusterin Canine E. coli
RD472034100-HEK Clusterin Canine HEK293
RD172034100 Clusterin Human HEK293
RD176034100 Clusterin Human HEK293 Tag free
RD172034100-S Clusterin Human NATIVE, Human Plasma
RD162034100 Clusterin Human NATIVE, Human Serum
RD372034100 Clusterin Rat E. coli
RD481034100 Clusterin Canine, Rabbit Polyclonal Antibody
RD484034100 Clusterin Canine, Sheep Polyclonal Antibody
RD182034110-H3 Clusterin Human, Mouse Monoclonal Antibody, Clone: Hs-3
RD381034100 Clusterin Rat, Rabbit Polyclonal Antibody  


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NEW EXTRACELLULAR MATRIX ASSAYS


CAT. NO. STATUS NAME ASSAY FORMAT
RBCK1000 Multispecies Keratin Orange, (110 assays) [Standard Kit] Colorimetric assay
RBCK5000 Multispecies Keratin Orange, (440 assays) [Economy Kit] Colorimetric assay

 For these and more Extracellular Matrix Assays, please visit www.biovendor.com/extracsellular-matrix-assays.


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