Gestational diabetes mellitus (GDM) is a heterogeneous multivariate pregnancy disease with complicated pathological mechanisms. In addition to inflammatory reaction, insulin resistance (IR) and abnormality of lipid and glucose metabolism, GDM also involves DNA methylation and oxidative stress signal transduction that affect cardiac function.
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The epidemic of obesity is now recognised as one of the most important public health problems facing the world today. Adult obesity is more common globally than under-nutrition.
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Are you wondering what the term “diabesity” stands for? It expresses the strong association between type 2 diabetes mellitus (T2DM) and obesity. 75–90% of patients with T2DM are overweight or obese, as obesity is one of the main risk factors for T2DM. Moreover, progression of obesity to T2DM can be partly explained by changes in adipose tissue composition and function.
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