Obstructive sleep apnea (OSA) is a respiratory disorder characterized by repeated and cyclic episodes of total collapse of the upper airway during sleep. These events may result in oxygen desaturation, high blood levels of carbon dioxide and microarousals.
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Sepsis is a recognized global health problem.
It affects over 30 million people worldwide annually and is the largest killer of children → 5 million each year.
Clusterin is one of the central stress response proteins. It exists in two variants. The major longer secreted form of clusterin (sCLU) exerts an anti-apoptotic function and the nuclear form (nCLU) has a pro-apoptotic function.
sCLU binds extracellularly to stressed and unfolded proteins to form a clusterin – damaged protein complex. This complex is subjected to either interaction with other chaperones in order to refold the damaged protein or interaction with cellular receptors resulting in lysosomal or proteasomal degradation inside the cell.
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