Obesity and overweight are a rapidly growing public health problem affecting an increasing number of countries worldwide because of its prevalence, costs, and health effects.
Obesity and being overweight, abnormal accumulation of body fat (usually 20% above the normal ideal body weight), are chronic disorders officially classified as a diseases (ICD-10 E66.0) in 1990 and defined as a body mass index (BMI) of 30 kg/m2 or more.
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Type-2 diabetes mellitus (T2DM) is a major health problem in the world and many studies have been done in this topic. Nowadays we can certainly say, that pathogenesis of T2DM is connected to obesity-associated insulin resistance and dysglycemia. Despite the fact, that individuals of South Asian descent have a higher risk of developing T2DM for a given body mass index (BMI) compared to Caucasians, majority of the published data was obtained by studying western populations. Moreover, in South Asians, different mechanisms could operate in the pathogenesis of these processes. The pressure for new data in this field is even higher because of recent escalation of obesity in this region.
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Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. Although sepsis is potentially life-threatening, the illness ranges from mild to severe.
Severe sepsis causes poor organ function and/or blood flow and can lead to septic shock. If sepsis progresses to septic shock, blood pressure drops dramatically. This may lead to death. Septic shock is a common cause of mortality mainly in critically ill patients. According to the Mayo Clinic, septic shock has close to a 40 percent mortality rate.
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